| 蛇床子和白芷中香豆素类化合物抑制磷酸二酯酶5活性的研究 |
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| 引用本文： | 尉小慧,张树军,夏广新,付收,王伟,沈敬山,嵇汝运.蛇床子和白芷中香豆素类化合物抑制磷酸二酯酶5活性的研究[J].中国药学杂志,2006,41(2):100-101. |
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| 作者姓名： | 尉小慧 张树军 夏广新 付收 王伟 沈敬山 嵇汝运 |
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| 作者单位： | 1. 中国科学院上海生命科学研究院上海药物研究所,上海,201203
2. 河南天方药业股份有限公司,河南,驻马店,463000 |
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| 摘 要： | 目的研究香豆素类化合物的PDE5抑制活性。方法用体积分数为95％乙醇和氯仿分别提取蛇床子及白芷中总香豆素类化合物,并通过柱色谱和HPLC进行分离,结构鉴定后进行PDE5抑制活性研究。结果分离得到8个化合物,结构修饰4 个化合物,并测得其PDE5抑制活性数据。结论蛇床子素具有较强的PDE5抑制剂。
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| 关 键 词： | 蛇床子 白芷 香豆素类 PDE5抑制剂 |
| 文章编号： | 1001-2494（2005）16-0100-03 |
| 收稿时间： | 2005-01-16 |
| 修稿时间： | 2005-01-16 |
Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5 |
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| WEI Xiao-hui,ZHANG Shu-jun,XIA Guang-xin,FU Shou,WANG Wei,SHEN Jing-shan,JI Ru-yun.Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5[J].Chinese Pharmaceutical Journal,2006,41(2):100-101. |
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| Authors: | WEI Xiao-hui ZHANG Shu-jun XIA Guang-xin FU Shou WANG Wei SHEN Jing-shan JI Ru-yun |
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| Institution: | 1. Shanghai Institute of Materia Medica , Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences , Shanghai 201203, China ; 2. Topfond Pharmaceutical Inc , Zhumodian 463000, China |
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| Abstract: | OBJECTIVE To study the activity of coumarins as PDE5 inhibitor.METHODS The coumarins were extracted with 95% alcohol from Cnidium monnieri(L.) Cusson and with CHCl3 from Angelica dahurica Benth.et Hook.,and then isolated via column chromatog-raphy and HPLC. After structure identification, the inhibition of compounds on PDE5 was investigated according to the existing methods. RESULTS 8 compounds were isolated and identified, and 4 compounds were obtained by structure modification. The activities data as PDE5 inhibitors were tested. CONCLUSION Osthol showes the potent inhibitation on PDE5. |
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| Keywords: | Cnidium monnieri(L ) Cusson Angelica dahurica Benth et Hook coumarins PDE5 inhibitor |
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