四硫化四砷动物药动学研究

 目的初步探讨四硫化四砷(As₄S₄)的动物药动学规律。方法原子分光光度法测定As₄S₄小鼠单次灌胃后血砷浓度以及组织、排泄物中总砷含量。以3P97软件进行药动学参数估算。结果小鼠单次灌胃As₄S₄的药-时变化符合一房室模型,吸收不完全,消除较慢,其消除半衰期9～12 h。口服给药后砷在小鼠体内分布广泛,主要分布在体脂、毛、皮、肝、肾、脾和子宫。砷主要从粪、尿排泄。结论小鼠灌胃As₄S₄血中和组织中能达到一定浓度,但是吸收有限,因而相对较为安全。消除半衰期较长,值得注意。

Pharmacokinetics of Tetra-Arsenic Tetra-Sulfide in Mice

OBJECTIVE To investigate the pharmacokinetic behavior after an intragastric(ig) administration of a single dose of tetra-arsenic tetra-sulfide(As₄S₄) in mice.METHODS Atomic absorption spectrometry was used to determine the total concentration of arsenic in bio samples,including blood,tissue and excreta.RESULTS The concentrationtime curves of As₄S₄ in blood after an ig of 3 different dosages in mice were discribed by an one-compartment model with the 1^st order absorption calculated by the program 3P97.The absorption of As₄S₄ was insufficient.It was eliminated slowly,with the half-life of about 9～12 h.Arsenic was widely distributed in many tissues,mainly in body fat,hair,skin,liver,kidney,spleen and uterus.It was mainly excreted in feces and urine.CONCLUSION Arsenic is detected in the blood and many tissues of mice after a single dose of As₄S₄.However,its absorption is insufficient,so that it is relative safe for ig administration.It is important that t_1/2(Ke) is long.