| 尼莫地平－聚乙二醇类固体分散物的制备及其体外溶出度的研究 |
| |
| 引用本文： | 陆锦芳,王妙珍.尼莫地平－聚乙二醇类固体分散物的制备及其体外溶出度的研究[J].中国药学杂志,1995,30(1):23-25. |
| |
| 作者姓名： | 陆锦芳 王妙珍 |
| |
| 作者单位： | 上海医科大学药学院药剂学教研室 |
| |
| 摘 要： | 尼莫地平在临床上应用较为广泛，但其生物利用度低，本文选用无生理活性的聚乙二醇（ＰＥＧ）为载体，以熔融法制备尼莫地平－ＰＥＧ固体分散物，经ＤＳＣ法和溶出度测定，认为尼莫地平与ＰＥＧ形成低共熔物，并使溶出度大大增加。方差分析结果表明，尼莫地平－ＰＥＧ固体分散物的溶出度与尼莫地平原粉溶出度之间有显著差异，固体分散物的溶出度基本上随ＰＥＧ分子量的增加而增加，尼莫地平与ＰＥＧ比例为１：９时，ＰＥＧ６０００与ＰＥＧ４０００、ＰＥＧ６０００与ＰＥＧ１００００形成的固体分散物的溶出度之间也有显著差异。
|
| 关 键 词： | 尼莫地平 聚乙二醇 固体分散物 低共熔物 |
| 收稿时间： | 1993-05-04; |
Preperation and dissolution of nimodipine-PEG solid dispersion |
| |
| Lu Jinfang,Wang Miaozhen,Ding Ping,Pan Zesheng.Preperation and dissolution of nimodipine-PEG solid dispersion[J].Chinese Pharmaceutical Journal,1995,30(1):23-25. |
| |
| Authors: | Lu Jinfang Wang Miaozhen Ding Ping Pan Zesheng |
| |
| Institution: | Department of Pharmaceutics,School of Pharmacy,Shanghai Medical University,Shanghai 200032 |
| |
| Abstract: | Nimodipine-PEG solid dispersion was prepared by meIting method.The formationof eutectic mixtures between drug and carrier was demonstrated by DSC and dissolution. The dissolution rate of the solid dispersion was larger than the pure drug. Statistical analysis showed sig-nificant difference between drug and solid dispersion. |
| |
| Keywords: | nimodipine polyethylene glycol solid dispersion eutectic mixture dissolution |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
| 点击此处可从《中国药学杂志》下载免费的PDF全文 |
