地黄苷A对"阴虚"及免疫功能低下小鼠的药理作用

目的 研究地黄苷A滋阴和调节免疫作用。方法 制备小鼠阴虚模型，观察地黄苷A对cAMP系统的影响；制备小鼠免疫功能低下模型，观察地黄苷A对血清溶血素、迟发性变态反应和腹腔巨噬细胞吞噬功能的影响。结果 地黄苷A可以使小鼠体重明显增加、血浆cAMP含量和cAMP/cGMP值明显降低；地黄苷A能明显提高小鼠血清溶血素水平，增强小鼠迟发性变态反应，而对腹腔巨噬细胞吞噬指数和吞噬系数无明显影响。结论 地黄苷A具有滋阴作用，增强体液免疫和细胞免疫功能，对非特异性免疫无明显作用。

Experimental study on rehmaionoside A in nourishing yin and regulating immune functions

OBJECTIVE To study the effects of rehmaionoside A on nourishing yin and regulating immune functions.METHDOS The yin deficiency models in mice were made and the effects of rehmaionoside A on the cAMP system were observed.Immunologic inadequacy models in mice were induced and the effects of rehmaionoside A on the level of serum hemolysin,delayed type hypersensitivity (DTH) and peritoneal macrophage phagocytic function were observed.RESULTS Rehmaionoside A obviously increased the weight,reduced the contents of plasma cAMP and ratio of cAMP/cGMP .Rehmaionoside A also significantly raised the levels of serum hemolysin,enhanced DTH in mice,but it had no effects on peritoneal macrophage phagecytic coefficient and index.CONCLUSION Rehmaionoside A had the effects on nourishing yin,enhancing humoral and cellular immune function.Its effect on nonspecific immunity was not evident.