| 聚乙二醇1000维生素E琥珀酸酯修饰多柔比星脂质体的制备和性质 |
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| 引用本文： | 王文喜,张楠,单伟光,高建青,梁文权.聚乙二醇1000维生素E琥珀酸酯修饰多柔比星脂质体的制备和性质[J].中国药学杂志,2011,46(17):1340-1343. |
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| 作者姓名： | 王文喜 张楠 单伟光 高建青 梁文权 |
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| 作者单位： | 浙江工业大学药学院;浙江大学药学院; |
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| 基金项目： | 浙江省自然科学基金资助项目(Y206534) |
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| 摘 要： | 目的 制备聚乙二醇1000维生素E琥珀酸酯(TPGS)修饰的脂质体，并对其理化性质进行考察。方法 采用薄膜超声法制备脂质体，用硫酸铵梯度法制备将多柔比星载入脂质体内，阳离子交换树脂吸附法测定药物包封率，用透析法测定其体外释放，透射电镜观察脂质体形态，激光粒度测定仪测定粒度分布和Zeta电势，并考查脂质体稳定常数Ke、药物泄漏率以及胎牛血清对脂质体粒度的影响。结果 TPGS修饰的脂质体形态规整，药物包封率为（95±2.13）%（n=3）；Zeta电位为-3.06 mV，平均粒径为68.7 nm，多分散指数为0.186；TPGS修饰后能显著提高脂质体的贮藏以及在血清中的稳定性，大大降低药物泄漏率，而体外释放快于普通脂质体。结论 TPGS修饰的多柔比星脂质体具有包封率高、粒径小、稳定性好等优点。
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| 关 键 词： | 脂质体 聚乙二醇1000维生素E琥珀酸酯 多柔比星 |
| 收稿时间： | 2011-11-11; |
Preparation and Characterization of TPGS-Modified Doxorubicin Liposomes |
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| WANG Wen-xi,ZHANG Nan ,SHAN Wei-guang,GAO Jian-qing,LIANG Wen-quan.Preparation and Characterization of TPGS-Modified Doxorubicin Liposomes[J].Chinese Pharmaceutical Journal,2011,46(17):1340-1343. |
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| Authors: | WANG Wen-xi ZHANG Nan SHAN Wei-guang GAO Jian-qing LIANG Wen-quan |
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| Institution: | WANG Wen-xi1,ZHANG Nan 1,SHAN Wei-guang1,GAO Jian-qing2,LIANG Wen-quan2(1.School of Pharmacy,Zhejiang University of Technology,Hangzhou 310014,China,2.College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China) |
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| Abstract: | OBJECTIVE To prepare doxorubicin liposomes modified by TPGS1000,and investigate their physicochemical properties.METHODS Liposomes were prepared by thin-film ultrasonic technology,and doxorubicin was remotely loaded by(NH4)2SO4-gradiend method.The encapsulation efficiency of doxorubicin was determined after cationic resin absorption.Drug release in vitro was carried out with dialysis bag;the morphological characterization of liposomes was observed by transmission electron microscopy;particle size distributi... |
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| Keywords: | liposome TPGS doxorubicin stability |
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