首页 | 本学科首页   官方微博 | 高级检索  
检索        

双氯芬酸对盐酸莫西沙星在大鼠体内的药动学影响
引用本文:董洁,陈晓乐,林高通,阚歆,张潇云,张秀华.双氯芬酸对盐酸莫西沙星在大鼠体内的药动学影响[J].中国药学杂志,2011,46(19):1509-1512.
作者姓名:董洁  陈晓乐  林高通  阚歆  张潇云  张秀华
作者单位:温州医学院;温州市第三人民医院;温州医学院附属第一医院;
摘    要: 目的 研究双氯芬酸对莫西沙星在大鼠体内药动学的影响。方法 采用平行对照实验设计,健康雄性SD大鼠18只随机分成2组,单用莫西沙星组(ig 40 mg·kg-1 )和双氯芬酸与莫西沙星联合使用组(ig 25 mg·kg-1双氯芬酸,ig 40 mg·kg-1莫西沙星)。采用HPLC测定莫西沙星的血药浓度。用DAS2.0程序计算主要药动学参数,并进行统计分析。结果 健康雄性SD大鼠灌胃给药:单用组、联用组莫西沙星ρmax分别为(6.7±1.1)和(4.4±1.0)mg·L-1,tmax分别为(0.9±0.2)和(1.2±0.2)h;AUC0-t 分别为(34.4±9.6)和(27.5±7.8)mg·h·L-1,AUC0-∞分别为(41.2±12.2)和(30.8±11.9)mg·h·L-1;t1/2分别为(9.0±5.7)和(6.2±3.7)h;Clz/F分别为(1.1±0.5)和(1.4±0.5) mL·h-1·g-1,联用组莫西沙星的AUC0-t、AUC0-∞ρmax均显著小于单用组(高侧P>0.05,低侧P<0.05),两组莫西沙星tmaxt1/2Clz/F比较无统计学意义(P>0.05)。结论 双氯芬酸和莫西沙星联合用于大鼠时,双氯芬酸使莫西沙星的AUC和ρmax减小,临床上应注意两药联用时的给药剂量的调整。

关 键 词:莫西沙星  双氯芬酸  药动学  高效液相色谱法
收稿时间:2012-01-01;

Effects of Diclofenac on Moxifloxacin Pharmacokinetics in Rats
DONG Jie,CHEN Xiao-le,LIN Gao-tong,KAN Xin,ZHANG Xiao-yun,ZHANG Xiu-hua.Effects of Diclofenac on Moxifloxacin Pharmacokinetics in Rats[J].Chinese Pharmaceutical Journal,2011,46(19):1509-1512.
Authors:DONG Jie  CHEN Xiao-le  LIN Gao-tong  KAN Xin  ZHANG Xiao-yun  ZHANG Xiu-hua
Institution:DONG Jie1,CHEN Xiao-le1,LIN Gao-tong1,KAN Xin2,ZHANG Xiao-yun1,ZHANG Xiu-hua3
Abstract:OBJECTIVE To develop a high performance liquid chromatography method for the determination of moxifloxacin in rat plasma.To study the effects of diclofenac on moxifloxacin pharmacokinetics in rats. METHODS Using parallel control design , 18 Sprague-Dawley Rats were randomly divided into 2 groups (n=9 each) group M, moxifloxacin without diclofenac and group DM, moxifloxacin with Diclofenac. In grouop M, rats were given 40 mg·kg-1 moxifloxacin orally; In grouop DM, rats were given 25 mg·kg-1 Diclofenac and 40 mg·kg-1 moxifloxacin orally. The concentrations of moxifloxacin in plasma were determined by HLPC. The pharmacokinetic parameters were calculated by DAS2.0 programme. RESULTS The obtained pharmacokinetic parameters of moxifloxacin in plasma were as follows ρmax in group M (6.7±1.1) mg·L-1 was significantly higher than that in group DM (4.4±1.0) mg·L-1, accompanied by significant increase of AUC0-t (34.4±9.6) mg·h·L-1 vs (27.5±7.8) mg·h·L-1 and AUC0-∞(41.2±12.2) mg·h·L-1 vs (30.8±11.9) mg·h·L-1 (high side P>0.05,low side P<0.05). No differences between two groups in tmaxt1/2 and Clz/F were found(P>0.05). CONCLUSION When Diclofenac and moxifloxacin are simultaneously used in rats, Diclofenac decreases AUC and ρmax of moxifloxacin. When both drugs are used in clinical application, the dosage should be restricted.
Keywords:moxifloxacin  diclofenac  pharmacokinrtic  HPLC  
本文献已被 CNKI 等数据库收录!
点击此处可从《中国药学杂志》浏览原始摘要信息
点击此处可从《中国药学杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号