基于铁死亡调控机制的抗肿瘤药物研究进展

铁死亡是近年来发现的一种新的程序性细胞死亡方式,以活性氧过度积累和脂质过氧化物堆积为主要特征.尽管目前铁死亡的作用机制尚不明确,但是铁死亡现象引起了研究者的广范关注,现已成为抗肿瘤研究新热点.为了更好地了解铁死亡,本研究对近年发表与铁死亡调控机制和铁死亡诱导剂研究相关的文献进行荟萃,以期为抗肿瘤药物的研发梳理出新思路.

Research Progress of Anti-Tumor Drugs Based on the Regulation Mechanism of Ferroptosis

As a non-apoptotic programmed cell death, ferroptosis was discovered in recent years. It is characterized by large accumulation of iron-dependent lipid peroxide(LPO) and reactive oxygen species(ROS) inside cells. Although its mechanisms are still not clear, the phenomenon of ferroptosis has attracted widespread attention and become a hot spot in anti-tumor research. In order to better understand ferroptosis and provide new ideas for the development of antitumor drugs, the regulatory mechanisms of ferroptosis and ferroptosis inducers published in recent years were reviewed.