| 有机锗Ge-132对氧自由基和由羟自由基诱导的脂质过氧化的影响 |
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| 引用本文： | 王巨存,朱铁梁.有机锗Ge-132对氧自由基和由羟自由基诱导的脂质过氧化的影响[J].中国药学杂志,1994,29(1):23-25. |
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| 作者姓名： | 王巨存 朱铁梁 |
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| 作者单位： | 天津医院骨科研究所药理室!300211(王巨存，邢国胜，胡文铎)，武警天津总队医院药局(朱铁梁)，天津第二医学院药学系(王倩，赵华) |
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| 摘 要： | 有机锗Ge-132对邻苯二酚自氧化过程中产生的超氧阴离子自由基具有清除作用,但比抗坏血酸弱;Ge-132对由Fenton反应产生的羟自由基具有清除作用,对羟自由基诱导的大鼠肝匀浆脂质过氧化具有抑制作用?在清除羟自由基抗脂质过氧化方面,Ge-132的作用强于甘露醇?
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| 关 键 词： | 羧乙基锗倍半氧化物 甘露醇 Ge-132 抗坏血酸 超氧阴离子血由基 羟自由基 脂质过氧化 |
| 收稿时间： | 1992-06-03; |
Effects of Ge-132 on oxygen free radicals and the lipid peroxidation induced by hydroxyl free radical in vitro |
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| WANG Ju-chun,XING Guo-sheng,HU Wen-duo,ZHU Tie-liang,WANG Qian,ZHAO Hua.Effects of Ge-132 on oxygen free radicals and the lipid peroxidation induced by hydroxyl free radical in vitro[J].Chinese Pharmaceutical Journal,1994,29(1):23-25. |
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| Authors: | WANG Ju-chun XING Guo-sheng HU Wen-duo ZHU Tie-liang WANG Qian ZHAO Hua |
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| Institution: | Tianjin Hospital; Tianjin 300211 |
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| Abstract: | The effects of Ge-132 on oxygen free radicals and hydroxyl free radical induced rat liver homogenate lipid peroxidation in vitro were studied. Superoxide anion free radical was scavenged by Ge-132, but its effect was weaker than ascorbic acid. Hydroxyl free radical was scavenged by Ge-132 and lipid peroxidation was inhibited ; both the effects were stronger than mannitol. |
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| Keywords: | carboxylethyl germanium sesquioxide Ge-132 mannitol superoxide anion frel radical hgdroxyl free radical lipid peroxidafion ascorbic acid |
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