阿霉素脂质体对小鼠的抗肿瘤活性比较

 目的:探讨阿霉素(Adr)脂质体对小鼠肝癌-22细胞( H₂₂)和肉瘤-180细胞( S₁₈₀ )肿瘤的杭种瘤活性。方法:将Adr包封于二棕桐酸磷脂酰胆碱(DPPC)和大豆甾醇(SS)以及含有聚乙二醇(PEG)的两种脂质体(DPPC/SS和DPPC/SS/PEG脂质体)中，连同游离Adr，共3种样品，分别对接种了H₂₂和S₁₈₀的小鼠进行了尾静脉注射治疗实验。结果:Adr脂质休对H₂₂腹水型肝癌和S_{180肉瘤的动物生命延长率和抑制效果优于游离的Adr，而且DPPC/ SS/PEG脂质体的杭癌效果更好。结论:将脂质体作为杭癌药物Adr的载体，对小鼠H22腹水癌和S180肉瘤的治疗有效。}

Antitumor efficacy of adriamycin encapsulated in liposomes in mice

OBJECTIVE: To investigate the antitumor activity of adriamycin liposomes (Adr liposomes) against H 22 and S 180 tumors in mice. METHODS: Adriamycin (Adr) was encapsulated in dipalmitoylphosphatidylcholine (DPPC) and soybean derived sterol (SS) as well as PEG DSPE liposomes (DPPC/SS liposomes and DPPC/SS/PEG liposomes). The two kinds of liposomes and free Adr were administered in the tail vein in H 22 and S 180 tumor bearing mice. RESULTS: The antitumor efficacy of Adr encapsulated in DPPC/SS liposomes and DPPC/SS/PEG liposomes was active than that of the free drug and the DPPC/SS/PEG liposomes were markedly active. CONCLUSION: These results indicate that liposomes delivery Adr may provide antitumor activity of Adr against H 22 and S 180 cancer.