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甲硝唑结肠定位微丸的制备及体外释放度研究
引用本文:罗昕,平其能,柯学,佘佐彦.甲硝唑结肠定位微丸的制备及体外释放度研究[J].中国药学杂志,2007,42(16):1233-1235.
作者姓名:罗昕  平其能  柯学  佘佐彦
作者单位:1. 中山大学药学院,广州,510080
2. 中国药科大学药剂教研室,南京,210009
摘    要: 目的制备甲硝唑结肠定位微丸,以体外释放度为指标,筛选合适的处方。方法采用水性包衣技术,以HPMC和EC为包衣材料制备时控型结肠定位微丸,以EC和Eudragit L30D-55为包衣材料制备pH依赖型结肠定位微丸。结果时控型结肠定位微丸6h释药量在20%左右,pH依赖型结肠定位微丸6h释药量在25%左右。结论体外试验表明,制剂具有较好的结肠定位效果。

关 键 词:甲硝唑  结肠定位微丸  流化包衣  体外释放度
文章编号:1001-2494(2007)16-1233-04
收稿时间:2006-03-06;
修稿时间:2006-03-06

Studies on Metronidazole Colon-specific Pellets and Its Release in Vitro
LUO Xin,PING Qi-neng,KE Xue,SHE Zuo-yan.Studies on Metronidazole Colon-specific Pellets and Its Release in Vitro[J].Chinese Pharmaceutical Journal,2007,42(16):1233-1235.
Authors:LUO Xin  PING Qi-neng  KE Xue  SHE Zuo-yan
Institution:1. School of Pharmaceutical Science, Zhongshan University, Guangzhou 510080, China ; 2. Department of Pharmaceutics , China Pharmaceutical University, Nanjing 210009, China
Abstract:OBJECTIVE To prepare metronidazole colon-specific pellets, and screen formulations according to the profile of release in vitro. METHODS By using aqueous coating technique, time-dependent controlled colon-specific pellets were prepared with HPMC and EC,and pH-dependent pellets were prepared with EC and Eudragit L30D-55. RESULTS Time-dependent controlled co- lon-specific pellets released about 20% and pH-dependent pellets released about 25% at 6 h. CONCLUSION Test in vitro showed preparations had colon-specific capability.
Keywords:metronidazole  colon-specific pellets  fluidized coating  release in vitro
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