淫羊藿提取液防治激素所致大鼠骨质疏松的实验研究

 目的：探讨淫羊藿提取液防治激素所致大鼠骨质疏松的疗效。方法：采用3月龄Sprague-Dawley大鼠24只，随机分为对照组(1组)、激素组(2组)和预防组(3组)。2组喂醋酸泼尼松(4.5 mg/kg)2次/周；3组除按2组同法喂泼尼松外，还同时喂淫羊藿提取液2.0 g/(kg·d)。3个月后对3组大鼠胫骨上段的骨片用图象分析仪进行测算和分析。结果：激素组与对照组比较，由于骨吸收大于骨形成，出现骨小梁面积和数量减少，骨小梁分离度增加。用淫羊藿提取液预防的激素组，骨吸收率比2组减少了70%，因而骨量接近正常组水平。结论：实验结果提示，淫羊藿提取液能预防激素所致的骨质疏松。

Epimedium sagittatumMaxim preventing hormone-induced osteoporosis in rats

OBJECTIVE:To study the therapeutic results of Epimedium sagittatum Maxim preventing hormone-induced osteoporosis in rats.METHOD:24 male Sprague-Dawley rats at 3 months of age were randomly divided into control,hormone and hormone-traditional Chinese medicine groups.The hormone group was fed prednisone acetate(4.5 mg/kg) twice a week and the hormone-traditional Chinese medicine group was given fluid abstracted from Epimedium sagittatum Maxim［2.0 g/(kg·d)］ besides administered prednisone similar to the hormone group.After the experiment lasted for 90 days,the histomorphometric parameters of slides of proximal tibia were measured and calculated in the three groups.RESULTS:The percentage of trabecular area and trabecular number(density) was decreased,and trabecular separation increased because of bone resorption exceeded the formation in the hormone group as compared with the control group.However,in the hormone-traditional Chinese medicine group,bone mass exceeded because of the bone resorption rate(70%) was less than that of the hormone group.CONCLUSION:The data suggest that prednisone acetate induced osteoporosis can be prevented by Epimedium sagittatum Maxim.