乳化聚合法制备阿苯达唑聚氰基丙烯酸酯纳米球的方法比较及稳定性考察

 目的优化乳化聚合法制备阿苯达唑聚氰基丙烯酸正丁酯纳米球的处方工艺。方法以包封率和载药量为指标，比较了一步、二步和三步乳化聚合法制备阿苯达唑纳米粒。采用均匀设计优化三步乳化聚合法(种子乳化聚合法)制备阿苯达唑纳米球处方工艺，并考察了光照、冷冻和温湿条件下对制剂稳定性的影响。结果三步乳化聚合法制备阿苯达唑包封率为(82±6)%，载药量为(56±5)%，显著地优于一步法和二步法(P＜0.01)，且具有良好的抗光、寒和湿热性。结论三步乳化制备阿苯达唑纳米球具有包封率和载药量高、质量稳定性的特点。

Studies on preparation of albendazole polybutycyanocrylate nanoparticles and its stability

OBJECTIVE To screen the formulation and the preparation technics of the albendazole nanoparticles.METHOD S The albendazole polybutycyanocrylate-nanoparticles (ABZ-PBCA-NP) were prepared with one-step,two-step and three-step emulsification polymerization respectively.The uniform design was used for seeking the optimum formulation and technics in three-step method.The stability of ABZ-PBCA-NP,which was made with optimum formulation,was studied in different temperatures，humidity and 3 000 lx illumination.RESULTS The entrapment efficiency and the quantity of drug-load in nanoparticles with three-step method were (82±6)% and (56±5)% respectively，which were remarkably higher than that by one-step and two-step methods.The stability study indicated that ABZ-PBCA-NP was able to resist the sunlight,humidity and cool.CONCLUSION The three-step emulsification polymerization is an effective method to produce the ABZ-PBCA-NP.