黄花中华苦荬菜化学成分研究

目的 研究干燥黄花中华苦荬菜全草的化学成分。方法 采用硅胶柱色谱、HPLC、重结晶等方法进行分离纯化，依据理化性质和波谱数据鉴定结构。结果 从黄花中华苦荬菜全草中分离得到15 个化合物，分别鉴定为chinensioide F(1)，chinensioide C(2)，胡萝卜苷(3)，6′-对羟基苯乙酰基-ixerin D(4)，对羟基苯乙酸甲酯(5)，对羟基苯乙醇(6)，3,5-二甲氧基-4-羟基苯丙醇(7)，10α-羟基-愈创木烷-12,6-内酯-3-酮(8)，β-谷甾醇(9)，chinensioide E(10)，chinensioide D(11)，ixerochinoside(12)，3β,10α-二羟基-4(15)，11(13)-愈创木二烯-12,6-内酯(13)，10α-羟基-11βH-4(15)-愈创木烯-12,6-内酯(14)，木犀草素-7-O-β-D-葡萄糖苷(15)。结论 化合物1为新化合物，命名为chinensiode F，4~7、12~14首次从该植物中分离得到。

Study on Chemical Constituents of Ixeris chinensis Nakai

OBJECTIVE To study the chemical constituents of Ixeris chinensis Nakai.METHODS The constituents were isolated by silica gel column chromatography,HPLC and recrystallization,and their structures were elucidated on the basis of spectral analysis.RESULTS Fifteen compounds were isolated and identified as Chinensioide F(1),Chinensioide C(2),daucosterol(3),6′-p-hydroxyphenylacetyl-Ixerin D(4),methyl-4-hydroxyphenylacetate(5),p-hydroxyphenylethanol(6),3,5-dimethoxy-4-hedroxyphenylpropynol(7),10α-hydroxy-guaia-12,6-lactone-3-keton(8),sitosterol(9),Chinensioide E(10),Chinensioide D(11),Ixerochinoside(12),3β,10α-dihydroxy-guaia-4(15),11(13)-diene-12,6-lactone(13),10α-hydroxy-11βH-guaia-4(15)-ene-12,6-lacton(14) and luteolin-7-O-β-D-glucoside(15).CONCLUSION Compound 1 is new(chinensiode F).Compound 4~7 and 12~14 were isolated from I.chinensis Nakai for the first time.