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红花黄色素抑制血小板激活因子介导的血小板活化作用的研究
引用本文:陈文梅,金鸣,吴伟.红花黄色素抑制血小板激活因子介导的血小板活化作用的研究[J].中国药学杂志,2000,35(11):741-744.
作者姓名:陈文梅  金鸣  吴伟
作者单位:北京市心肺血管疾病研究所,北京
基金项目:国家自然基金项目!(396 70 884)
摘    要: 目的 观察血小板激活因子(PAF)对血小板聚集性、5-HT释放、胞浆内游离钙离子浓度的影响及红花总黄色素的抑制作用。方法 红花水煎液经硅胶吸附法除杂质得到红花总黄色素,以比浊法及邻苯二甲醛(OPT)荧光分光光度法观察其对PAF诱导家兔洗涤血小板(WRP)聚集及5-HT释放的影响。以Fura-2荧光分光光度法测定血小板内游离钙离子浓度。结果 红花总黄色素抑制PAF诱发的WRP聚集、5-HT释放作用呈明显的量效关系。PAF 2.0×10-9 mol·L-1时,0.21,0.42,0.85,1.69 g·L-1红花总黄色素血小板聚集抑制率依次为28.0%,32.9%,60.0%,79.4%;5-HT释放抑制率分别为4.70%,12.9%,32.9%,58.4%;同时4.1,6.5,10.3,16.7,26.7 mg·ml-1红花总黄色素剂量依赖地抑制8×10-10 mol·L-1 PAF引起的血小板内游离钙增高。结论 红花总黄色素可抑制PAF诱导的血小板聚集、5-HT释放及血小板内游离钙增加。

关 键 词:红花总黄色素  血小板激活因子  血小板聚集  5-羟色胺  血小板内游离钙
收稿时间:2000-03-06;
修稿时间:2000-03-06

Inhibition of safflor yellow on rabbit platelet activation induced by platelet activating factor
CHEN Wen mei,JIN Ming,WU Wei,LI Jin rong,YANG Shu dong.Inhibition of safflor yellow on rabbit platelet activation induced by platelet activating factor[J].Chinese Pharmaceutical Journal,2000,35(11):741-744.
Authors:CHEN Wen mei  JIN Ming  WU Wei  LI Jin rong  YANG Shu dong
Institution:Beijing Heart and Lung Blood Vessel Medical Center,Beijing 100029,China
Abstract:OBJECTIVE To observe the inhibition effect of safflor yellow on the platelet aggregation,5-HT relation,intercellular free calcium concentration elevation induced by platelet activating factor (PAF). METHODS Safflor yellow was prepared from water abstract of Carthamus tinctorius L.with silicon gel adsorption.The platelet aggregation and 5-HT relation were studied by turbidimetry and OPT fluorescence assay.The inner free calcium concentration was measured with fura-2/AM probe fluorescent technique. RESULTS It was shown that the inhibition effects of safflor yellow on PAF (2.0×10-9mol·L-1)induced platelet aggreation and platelet 5-HT release were dose-dependent.The inhibitive incidences of safflor yellow (0.21,0.42,0.85,1.69 g·L-1) on platelet aggregation or 5-HT release were 28.0%,32.9%,60.0%,79.4% or 4.74%,12.9%,32.9%,58.4%,respectively.It was found that safflor yellow (4.1,6.5,10.3,16.7,26.7 mg·L-1) inhibited the elevation of inner free calcium concentration of platelet evoked by PAF (8.0×10-10 mol·L-1) dose-dependentently. CONCLUSION The rabbit platelet activation induced by platelet activating factor can be inhibited by safflor yellow.
Keywords:safflor yellow  platelet aggregation  PAF  5-HT  free calcium
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