使用氨溴索对于术后肺保护效果的系统评价

 目的 评价氨溴索对于术后肺保护的疗效和安全性。方法 计算机检索Cochrane图书馆、PubMed数据库、Embase数据库、ISI数据库、中国生物医学文献数据库（CBMdisc）、中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、万方数字化期刊全文库，纳入氨溴索对比常规/安慰剂对于术后肺保护的随机对照试验（RCT）、系统评价（SR）和Meta分析文献，对纳入文献的随机对照试验进行方法学质量评价和Meta分析，参考纳入文献的系统评价和Meta分析结论。结果 氨溴索对比常规/安慰剂组对于术后肺保护共纳入12个RCT。两组术后肺部并发症发生率差异有统计学意义RR 0.55，95%CI(0.40， 0.74)]， P=0.000 1。控制术后痰量有效率差异有统计学意义RR 1.25，95%CI(1.09， 1.44)]， P=0.001；术后咳痰容易度差异有统计学意义RR 1.24，95%CI(1.12， 1.38)]， P

Efficacy and Safety of Ambroxol for Lung Protection in Perioperative Period:A Systematic Review

OBJECTIVE To review the efficacy and safety of ambroxol for lung protection in perioperative period.METHODS Random controlled trails(RCTs),systematic review(SR),and meta-analysis of ambroxol for lung protection in perioperative period were searched in Cochrane,PubMed,Embase,ISI,CBMdisc,CNKI,VIP and Wangfang dababase;the methodology quality of every RCT was evaluated,then meta-analysis was performed by software of RevMan5.0.0.RESULTS Twelve RCTs of ambroxol for lung protection in perioperative period were included.According to the meta-analysis results,the ambroxol group was better than the control group in pulmonary complications,The cough and expectoration degree in the ambroxol group was better than the control group.The ambroxol group was also better than the control group in sputum volume.ADR had no significant difference between the ambroxol and control groups.CONCLUSION Using ambroxol for lung protection in perioperative period can improve post-operativerespiratory system symptoms and reduce pulmonary complications.Ambroxol has a satisfactory lung protective effect in the preoperative period.