拉米夫定与原儿茶酸在大鼠体内的药动学相互作用

 目的 研究拉米夫定与原儿茶酸联合使用对各自在大鼠体内药动学的影响。方法 将wistar大鼠随机分为拉米夫定组（100 mg·kg-1，原儿茶酸组（100 mg·kg-1，拉米夫定+原儿茶酸组（100+100 mg·kg-1，每组6只，单次灌胃给药后，于不同时间点采集血样。用HPLC测定大鼠血药中拉米夫定与原儿茶酸的浓度，血药浓度-时间数据采用3P97软件进行药动学分析。结果 与两种药物单独使用相比，联用后拉米夫定的V/F显著减小，AUC_0-t显著增大，t1/2ka极显著增大，tpeak显著增大，CL/F极显著减小；原儿茶酸的t1/2β显著增大，t1/2ka、tpeak极显著增大。结论 两药联用使用后，存在明显的药动学相互作用。

Pharmacokinetic Interaction of Lamivudine and Protocatechuic Acid in Rats

OBJECTIVE To explore the pharmacokinetic interaction of lamivudine and protocatechuic acid. METHODS Wistar rats were given a single ig dose of lamivudine (100 mg·kg-1， protocatechuic acid (100 mg·kg-1， or lamivudine + protocatechuic acid (100+100 mg·kg-1， respectively. Plasma was collected at different time after drug administration. The concentrations of lamivudine and protcatechuic acid in plasma were determined by HPLC method. The plasma concentration-time data was analyzed with 3P97 software package to obtain the pharmacokinetic parameters of lamivudine and protocatechuic acid. RESULTS Compared with lamivudine administration group， V/F(c of lamivudine in the co-administration group significantly decreased， along with significant increase of AUC_0-t， t1/2ka， tpeak and CL/F(s. Meanwhile， t1/2β， t1/2ka and tpeak of protocatechuic acid in the co-administration group all significantly increased compared with those of protocatechuic acid administration group. CONCLUSION There exists obvious pharmacokinetic interaction when lamivudine and protocatechuic acid are co-administered to rats.