替硝唑在汉族健康人体的药动学

 目的研究汉族健康志愿者单剂量po替硝唑片的药动学。方法健康志愿者10名(其中男性5名,女性5名),单剂量po替硝唑片剂1 g,采用高效液相色谱法测定血浆中替硝唑的含量。用DAS软件程序进行数据处理,用SPSS软件对不同性别药动学参数进行统计分析。结果受试者单剂量po 1 g替硝唑的主要药动学参数:ρ_max为(19.04±2.42)mg·L^-1,t_max为(2.15±0.47)h,t_1/2为(16.94±2.40)h,AUC_0-72h为(454.37±59.74)mg·h·L^-1,AUC_0-∞为(486.14±65.63)mg·h·L^-1。结论汉族健康志愿者单剂量po替硝唑片的体内药动学过程符合一室模型。经统计学分析,汉族健康志愿者药动学过程存在性别差异。

Pharmacokinetics of Tinidazole in Chinese Healthy Volunteers

OBJECTIVE To study the pharmacokinetics of tinidazole tablets after a single oral dose in Han healthy volunteers.METHODS Five healthy male volunteers and five healthy female volunteers were involved in the study.Each subject received a single dose of 1 g tinidazole tablets.The plasma concentration was determined by HPLC.The pharmacokinetic parameters were calculated by DAS software and were statistical analyzed by SPSS software.RESULTS The main pharmacokinetic parameters were as follows: ρ_max was(19.04±2.42) mg·L^-1,t_max was(2.15±0.47) h,t_1/2 was(16.94±2.40) h,AUC_{0-72 h} was(454.37±59.74) mg·h·L^-1,AUC_0-∞ was(486.14±65.63) mg·h·L^-1.CONCLUSION The results showed that the plasma concentration-time curve of tinidazole were fitted to an one-compartment model and the main pharmacokinetic parameters of tinidazole have significant differences between male and female volunteers.