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化学计量学在中药苦荞麦指纹谱最佳检测波长选择中的应用
引用本文:张琪,张雪辉,陈建民.化学计量学在中药苦荞麦指纹谱最佳检测波长选择中的应用[J].中国药学杂志,2003,38(6):419-422.
作者姓名:张琪  张雪辉  陈建民
作者单位:中国医学科学院-中国协和医科大学药用植物研究所,北京,100094
摘    要: 目的确定通过高效液相色谱-二极管振列检测器法(HPLC-DAD)获得的中药苦荞麦指纹图谱的最佳检测波长。方法借助于化学计量学方面对有关信息的提取与处理获得相对峰面积之和、分离度之和、平均分离度经验参数的指标参数值及2个基于互信息理论的两个指标参数的计算,获得5个波长下的信息量值。结果这些指标参数及信息量值都能较好的反映不同检测条件下苦荞麦化学特征指纹图谱的分离质量。结论这些指标参数的表达式在本质上是一致的,都可以用来客观地评价同一检测条件、不同检测波长下得到的中药化学特征指纹图谱的分离质量。

关 键 词:苦荞麦  中药指纹图谱  最佳检测波长
文章编号:1001-2494(2003)06-0419-04
收稿时间:2002-06-04;
修稿时间:2002年6月4日

Application of chemoetrics in the choice of the best detection wavelength of the fingerprints of Fagopyrum tatarium Gaertn
ZHANG Qi,ZHANG Xue-hui,CHEN Jian-min.Application of chemoetrics in the choice of the best detection wavelength of the fingerprints of Fagopyrum tatarium Gaertn[J].Chinese Pharmaceutical Journal,2003,38(6):419-422.
Authors:ZHANG Qi  ZHANG Xue-hui  CHEN Jian-min
Institution:Chinese Academy of Medical Science & Peking Union Medical College,Institute of Medicinal Plant Development,Beijing 100094,China
Abstract:OBJECTIVE To define the best detection wavelength of the fingerprint of Fagopyrum tatarium Gaertn which was obtained by HPLC DAD.METHOD The necessary infomation was extracted and processed by means of some methods of chemical metrology,and then the index parameters such as SRPA (Sum of relative peak area),SR (Sum of resolution),MR (Mean of resolution) and WSK (a experience parameter) were obtained.The information values of five wavelengths were obtained through the calculation of two index parameters of the function of mutual information.RESULT Those parameters and information values reflected the isolation quality of the chemical characteristic fingerprint of Fagopyrum tatarium Gaertn.CONCLUSION The expressions of those parameters were consistent with intrinsic qualities.They can be used to judge the isolation quality of the chemical characteristic fingerprint of traditional Chinese medicine.
Keywords:Fagopyrum tatarium  Gaertn  the chromatographic fingerprint  chemometrics
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