心脉神胶囊对模拟高原急性缺氧大鼠肺动脉压力的作用机制研究

目的：探讨心脉神胶囊对急性缺氧大鼠肺动脉压力的影响。方法：将27只Wistar大鼠随机分为正常对照组、模型组与心脉神组,分别给予生理盐水、心脉神（0.45 g/kg·bw）连续7 d后,模型组与心脉神组置于低压氧舱内3 d,用多道生理记录仪测定肺动脉压力（PAP）。结果：与模型组比较,心脉神组肺动脉收缩压、舒张压、平均压均显著降低（P〈0.05或P〈0.01）。结论：心脉神胶囊对大鼠急性缺氧所致的肺动脉升高有抑制作用。

The Research of Xinmaishen Capsule on Acute Hypoxic Rats Simulated Plateau of Arteries and Veins of Pulmonary Artery Pressure Mechanism

Objective To investigate the effect of Xinmaishen capsule on acute hypoxic pulmonary artery pressure and car-diac function in rats. Methods： Wistar rats were randomly divided into normal control group, model group and Xinmaishen group,which were given normal saline, normal saline and Xinmaishen （0.45 g/kg bw） respectively for 7 days. Model group and Xin-maishen group were in low pressure oxygen situation for 3 days, and multichannel physiologic recorder is used to testpulmonaryartery pressure （PAP）. Results： Compared to the model group, the pulmonary artery systolic pressure, diastolic blood pressure andthe average pressure decreased significantly in Xinmaishen group （P〈0.05 or P〈0.01）. Conclusion： Xinmaishen showed inhibitoryeffect on the acute hypoxia pulmonary on rats caused by acute hypoxia.