健脾理气方对功能性消化不良模型大鼠NOS2表达的影响

目的:研究健脾理气方对功能性消化不良(FD)大鼠胃窦组织中一氧化氮合酶(NOS2)表达的影响,探讨该方治疗FD的作用机制。方法:以FD大鼠为实验对象,观察健脾理气方对FD大鼠胃窦组织中NOS2的表达的影响。结果:模型组大鼠胃窦组织中NOS2的表达阳性神经元表达明显减少(P﹤0.01),差异有统计学意义。健脾理气方各剂量组均可不程度地降低模型大鼠胃窦组织中NOS2的表达(P﹤0.05或P﹤0.01),且高剂量组与莫沙比利组作用差异无统计学意义(P>0.05)。结论:健脾理气方能通过降低胃黏膜组织NOS2的表达,抑制了NO的合成而发挥促胃动力作用。

Plenty of spleen party functional indigestion rat models NOS2 express influence

Objective: to study the regulating qi to spleen party functional indigestion(FD) rat gastric antrum organization of nitric oxide synthase(NOS2),this paper discusses the influence of the expression of the party the mechanism of action of FD treatment.Methods: to FD for experimental rats object,spleen,regulating qi to observe party FD rats in the expression of the gastric antrum organization NOS2 influence.Results: the model rats in the gastric antrum organization NOS2 express positive neurons express significantly reduced(P﹤0.01),a statistically significant difference.Each dose group of spleen,regulating qi party are not degree to reduce rat models in the expression of the gastric antrum organization NOS2(P﹤0.05 or 0.01),and ﹤ P high dose group and the sand Billy group difference was statistically significant role(P>0.05).Conclusion: the spleen,regulating qi by lowering the gastric mucosa tissue can NOS2 expression,curb the synthesis and play and NO stomach dynamic function.