A cytotoxic carotenoid from the marine sponge Prianos osiros |
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Authors: | Rogers Evan W Molinski Tadeusz F |
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Institution: | Department of Chemistry, University of California, Davis, California 95616, USA. |
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Abstract: | Investigations of the marine sponge Prianos osiros, collected in Pohnpei, gave a new cytotoxic acetylenic carotenoid, (3R,3'R,5S)-3,3',5,19'-tetrahydroxy-7',8'-didehydro-gamma,epsilon-carotene-8-one. The absolute configuration of this carotenoid was solved by interpretation of IR, MS, and 2D NMR spectra and application of the modified Mosher's method. Compound 1 is cytotoxic toward cultured human colon tumor cells, HCT 116 (IC(50) 4.38 microg/mL). |
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