New macrolactins from a marine Bacillus sp. Sc026 |
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Authors: | Jaruchoktaweechai C Suwanborirux K Tanasupawatt S Kittakoop P Menasveta P |
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Institution: | Departments of Pharmacognosy and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. |
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Abstract: | Bioassay-guided fractionation of the EtOAc extract of a marine Bacillus sp. Sc026 culture broth has led to the isolation of the known compound, macrolactin F (1), together with two new compounds, 7-O-succinyl macrolactin F (2) and 7-O-succinyl macrolactin A (3). The chemical structures of 1-3 were elucidated on the basis of spectral data analyses and literature data comparison. Compounds 1-3 exhibited antibacterial activity against Bacillus subtilis and Staphylococcus aureus. |
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