Daucane sesquiterpenes from Ferula hermonis |
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| Authors: | Galal A M Abourashed E A Ross S A ElSohly M A Al-Said M S El-Feraly F S |
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| Affiliation: | National Center for Natural Products Research, Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677, USA. amgalalv@yahoo.com |
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| Abstract: | The roots of Ferula hermonis Boiss yielded two new daucane esters, 14-(4'-hydroxybenzoyloxy)dauc-4,8-diene (1) and 14-(4'-hydroxy-3'-methoxybenzoyloxy)dauc-4,8-diene (2), together with the four known sesquiterpenes jaeschkeanadiol p-hydroxybenzoate (3), jaeschkeanadiol benzoate (4), jaeschkeanadiol (5), and epoxyjaeschkeanadiol (6). The identities of the isolated compounds were ascertained primarily using NMR and MS data. Compounds 1 and 3 exhibited antimicrobial activity against Staphylococcus aureus with IC(50) 1.5 and 3.5 microg/mL, respectively, and against Methicillin-resistant S. aureus with IC(50) 2.0 and 4.0 microg/mL, respectively. |
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