Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus |
| |
| Authors: | Manam Rama Rao Teisan Sy White Donald J Nicholson Benjamin Grodberg Jennifer Neuteboom Saskia T C Lam Kin S Mosca Deborah A Lloyd G Kenneth Potts Barbara C M |
| |
| Institution: | Nereus Pharmaceuticals Inc., 10480 Wateridge Circle, San Diego, CA 92121, USA. |
| |
| Abstract: | A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
