葛根素及噻吗心安滴眼液对实验性近视眼的作用

目的观察葛根素滴眼液和噻吗心安滴眼液对小鸡形觉剥夺性近视眼模型的治疗作用。方法40只小鸡随机分为模型组、噻吗心安组、葛根素组及阿托品组，于出生当日行右侧眼睑缝合诱导近视发生，左眼为对照眼。次日除模型组外，其余各组分别给予0．5％噻吗心安滴眼液，1％葛根素滴眼液，1％阿托品滴眼液滴右眼，每日3次。1月后拆开缝合的眼睑，验光检影，测眼压及眼轴。结果①1月后各组右侧缝合眼均形成不同程度近视，对照眼为轻度远视，两眼相比差异有极显著性意义（P〈0．01）；模型组右眼多为高度近视，噻吗心安组、葛根素组及阿托品组屈光度均小于模型组右眼，差异有显著性意义（P〈0．01）；葛根素组与阿托品组屈光度比较无显著性意义（P〉0．05）。②实验性近视眼眼轴随屈光度增高而增加并成正相关（P〈0．01），眼压与屈光度有显著相关性（P〈0．05）。结论葛根素滴眼液对小鸡实验性近视眼的发展有较好抑制作用，与阿托品疗效相当，可望成为一种治疗近视眼的新药；噻吗心安滴眼液对小鸡实验性近视眼的发展有一定抑制作用，其机制有待进一步研究。

Effects of puerarin and timolol eye drop on the chicken model of form deprivation myopia

OBJECTIVE To study the effects of puerarin, timolol on the chicken model of form deprivation myopia （FDM）. METHODS Forty chickens were divided into four groups randomly. The right eyes of these chickens were form - deprived by Lid Suture on the first day, the left eyes were control eyes. On the next day, the first group did not receive any medicine, the second group received 0.5 % timolol, the third one received 1% puemrin, and the fourth one received 1% atropine. One month later, diopter, axial length and intraocular pressure were measured （IOP）. RESULTS 1. There was significantly different between deprived eyes and control eyes（ P 〈 0.01）.The model group was significant difference compared with treated groups（ P 〈 0.01）.The puerarin group has no statistical significance compared with the atropine group（ P 〉 0.05）.2. There was a significant positive correlation between myopic diopter and axial length（ P 〈 0.01 ）. The axial length of myopia went up with the increasing of diopter. The diopter and IOP in myopia have significant correlation （P 〈 0.05）. CONCLUSIONS Puerarin can prevent deprivation myopia. Timolol can reduce form deprivation myopia, but it is not better than puerarin.