中医综合方案对大肠癌患者术后化疗不良反应的影响

目的:对中医综合方案对大肠癌患者术后化疗不良反应的影响进行分析。方法:以本院2012年1月—2013年5月收治的80例经手术治疗后化疗的大肠癌患者作为研究对象,随机分为辅助中医治疗组和单纯化疗组,每组各40例。对照组患者采用单纯化疗,观察组患者则在此基础上加以中医综合治疗(艾迪针或鸦胆子油乳),两组患者均治疗6个月后,对其临床症状、体力状况评分、血细胞、T细胞亚群的变化情况进行比较和分析。结果:①中医治疗组患者其化疗后不良反应的发生率明显低于单纯化疗组患者,且在毒性分度方面也存在显著性差异(P<0.05);②治疗后中医治疗组患者其评分明显高于单纯化疗组(P<0.05);③化疗后中医治疗组患者其CD+4水平以及CD+4/CD+8值均较单纯化疗组患者明显增高,而CD+8水平则明显降低,差异均具有统计学意义(P<0.05)。结论:中医综合方案可以有效减少大肠癌患者术后化疗不良反应的发生率,同时对改善患者体力和免疫力均有明显的促进作用。

Influence Analysis of Integrated Scheme Therapy of Traditional Chinese Medicine for Postoperative Adverse Reaction of Chemotherapy in Patients with Colorectal Cancer

Objective：To analyze the influence of integrated scheme therapy of traditional Chinese medicine for postoperative adverse reaction of chemotherapy in patients with colorectal cancer. Methods ：80 cases of chemotherapy of patients with colorectal cancer after surgical treatment who were treated in our hospital from January 2012 to May 2013 were as the research objects, and were randomly divided into the traditional Chinese medicine treatment group （the TCM group） and the pure chemotherapy group, each group had 40 cases. The patients in pure chemotherapy group were treated by chemotherapy alone, and the patients in the TCM group were treated by integrated scheme therapy of traditional Chinese medicine on the basis of chemotherapy （ Aidi needle or Yadanzi oil emulsion）. The clinical symptoms,physical status score, blood cells, the change of T cell subgroup in patients of two groups were compared and analyzed after 6 months＇treatment. Results ： （ 1 ）The incidence of the adverse reactions after chemo- therapy in patients of the TCM group was significantly lower than that in patients of the pure chemotherapy group, and the toxicity index also existed obvious difference between the two groups （ P 〈 0. 05 ）. （2） The KPS score after treatment in patients of the TCM group was significantly higher than that in patients of the pure chemotherapy group（P 〈 0.05 ）. （3） The levels of CD4 and CD4/CD8 values after chemotherapy in patients of the TCM group was significantly higher than that in patients of the pure chem- otherapy group,while the level of CDs was significantly reduced, and the differences were statistically significant （ P 〈 0.05 ）. Conclusion：The integrated scheme therapy of traditional Chinese medicine can effectively reduce the incidence of postoperative adverse reaction of chemotherapy in patients with colorectal cancer, at the same time it plays an obvious role in promoting the physical and immunity of patients.