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地黄甙D滋阴补血和降血糖作用的实验研究
引用本文:于震,王军,李更生,王玉升.地黄甙D滋阴补血和降血糖作用的实验研究[J].辽宁中医杂志,2001,28(4):240-242.
作者姓名:于震  王军  李更生  王玉升
作者单位:河南省中医药研究院,河南,郑州,450004
基金项目:国家中医药管理局资助项目! (95 Y3411),国家九五科技攻关项目! (96 -90 3-0 2 -0 4)
摘    要:应用甲状腺片和利血平片灌胃造成小鼠阴虚模型 ,利用环磷酰胺腹腔注射造成小鼠血虚模型 ,应用四氧嘧啶尾静脉注射造成小鼠糖尿病模型 ,给予地黄甙 D治疗 ,对小鼠体重、血浆 c AMP、c GMP含量 ,血常规和血小板计数、网织红细胞数、脾脏指数和骨髓 DNA含量 ,血糖进行检测。结果 :1地黄甙 D可以使阴虚模型小鼠体重明显增加、血浆 c AMP含量明显降低 ;2地黄甙 D可明显升高血虚模型小鼠白细胞数、血小板数、网织红细胞数和骨髓 DNA含量及体重 ;3地黄甙 D具有降低糖尿病模型小鼠血糖的趋势

关 键 词:地黄甙D  阴虚  血虚  糖尿病  动物模型  实验研究
文章编号:1000-1719(2001)04-0240-03
修稿时间:2000年12月30

Experimental Study on Rehmaionoside D in the Action of Nourishing yin, Enriching the Blood and Reducing the Blood Sugar
YU Zhen,WANG Jun,LI Geng sheng,WANG Yu sheng.Experimental Study on Rehmaionoside D in the Action of Nourishing yin, Enriching the Blood and Reducing the Blood Sugar[J].Liaoning Journal of Traditional Chinese Medicine,2001,28(4):240-242.
Authors:YU Zhen  WANG Jun  LI Geng sheng  WANG Yu sheng
Abstract:The yin deficiency models in mice were induced by oral administration of thyroid tablet and reserpine,the blood deficiency models in mice were induced by intraperitoneal injection of cyclophosphamide,the diabetes models in mice were induced by caudal intravenous injection of alloxon.Rehmaionoside D was used in treating the models,the levels of weight,contents of plasma cAMP and cGMP,blood routine examination and platelet count,reticulocyte count,spleen index,contents of bone marrow DNA and blood sugar were detected.Results:①Rehmaionoside D could significantly increase the weight,reduce the contents of plasma cAMP in yin deficiency model mice.②Rehmainonoside D could obviously raise the counts of white blood cell,platelet,reticulocyte,the contents of bone marrow DNA and the weight in blood deficiency model mice.③Rehmainonoside D had the trend to reduce the blood sugar in diabetes model mice.
Keywords:Rehmaionoside D  yin deficiency  blood deficiency  diabete  animal model  experimental study
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