大黄牡丹汤及其加减方治疗阑尾周围脓肿的系统评价

目的:系统评价国内大黄牡丹汤及其加减方治疗阑尾周围脓肿的随机对照试验的疗效。方法:根据纳入标准搜集相关文献,筛选合格研究,应用Cochrane系统评价手册4.2.8版标准结合Jadad评分法进行质量评价,运用异质性检验、Meta分析等方法统计相关数据。结果:检索到符合纳入标准文献9篇。Jadad评分普遍分数不高。Meta分析结果显示:①总有效率:合用抗生素对照抗生素RR=1.18,95%CI(1.13,1.24)有统计学意义;合大承气汤灌肠对照抗生素RR=1.10,95%CI(0.91,1.33)无统计学意义。②治愈率:合用抗生素对照抗生素RR=2.58,95%CI(1.84,3.61)有统计学意义。③体温正常时间:合用抗生素对照抗生素RR=-1.80,95%CI(-3.10,-0.50)有统计学意义;合大承气汤灌肠对照抗生素RR=-2.50,95%CI(-3.49,-1.51)有统计学意义。④平均住院时间:合用抗生素对照抗生素RR=-4.45,95%CI(-5.34,-3.57)]有统计学意义。⑤白细胞恢复正常时间:合用抗生素对照抗生素RR=-1.00,95%CI(-2.18,0.18)无统计学意义。⑥脓肿最早消退时间方面:合用抗生素及针灸疗法对照抗生素有优势。⑦包块平均缩小率方面:合大承气汤对照抗生素有优势。结论:有限证据表明大黄牡丹汤及其加减方结合抗生素对照抗生素有疗效优势,但是相关试验存在一定的方法学问题,尚需更多高质量的随机对照试验来进一步验证。

Appendiceal Abscess Treated by Dahuang Mudan Decoction,Its Varied Formula:A Systematic Review

Objective:To evaluate curative effect of Dahuang Mudan Decoction and its variation formula in treating appendiceal abscess.Methods:To gather randomized clinical trials of appendiceal abscess treated by Dahuang MUdan Decoction and its varied formula,and to select qualified trials.The handbook of Cochrane Collaboration's RevMan 4.2.8 and the Jadad scoring were used to assess the quality of RCT.Heterogeneity test and Meta-analyses etc.were used to compile statistics.Results:There were 9 RCTs included according...