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培土生金对脾虚哮喘大鼠气道环核苷酸水平的影响
引用本文:孙晓玲,闫英海,张庆荣.培土生金对脾虚哮喘大鼠气道环核苷酸水平的影响[J].辽宁中医杂志,2001,28(8):507-508.
作者姓名:孙晓玲  闫英海  张庆荣
作者单位:辽宁中医学院,
摘    要:为探讨培土生金法对哮喘治疗的作用机制。建立大鼠哮喘的脾气虚病证结合模型 ,对其支气管肺泡灌洗液中细胞总数 (Tot)、嗜酸性粒细胞数 (Eos)及环核苷酸 (cAMP和cGMP)含量及二者比值变化进行了观察。结果 ,培土生金中药对脾虚哮喘和哮喘动物均可降低其Tot、Eos(P <0 0 1或P <0 0 5 ) ,降低cGMP含量 ,升高cAMP含量和cAMP/cGMP比值 (P <0 0 1或P <0 0 5 )。结论 ,培土生金中药可能通过调整cAMP/cGMP比值而对哮喘起到防治作用。

关 键 词:培土生金  脾虚哮喘  动物模型  环磷酸腺苷  环磷酸鸟苷
文章编号:1000-1719(2001)08-0507-02
修稿时间:2001年4月24日

Effect of Strengthening Earth to Support Metal Method on Trachea cAMP and cGMP Level of the Asthmatic Rats with Spleen Deficiency
SUN Xiao-ling,YAN Ying-hai,ZHANG Qing-rong.Effect of Strengthening Earth to Support Metal Method on Trachea cAMP and cGMP Level of the Asthmatic Rats with Spleen Deficiency[J].Liaoning Journal of Traditional Chinese Medicine,2001,28(8):507-508.
Authors:SUN Xiao-ling  YAN Ying-hai  ZHANG Qing-rong
Abstract:Objective:To study the mechanism of the effect of the method of "strengthening earth to support metal" in treating asthma.Methods:The rat asthmatic models with spleen deficiency were set up,investigating the changes of total cell count(Tot),eosinophil count(Eos),the contents of cAMP and cGMP in bronchoalveolar lavage fluid of the animal models.Results:Experimental study showed that the medicine of "reinforcing earth to strengthen metal" can notably reduce the counts of Tot and Eos(P<0.01 or P<0.05),and the content of cGMP;and raise the content of cAMP and the ratio of cAMP and cGMP in model animals(P<0.01 or P<0.05).Conclusion:The medicine of "reinforcing earth to strengthen metal" might prevent and treat asthma through adjusting the ratio of cAMP and cGMP.
Keywords:strengthening earth to support metal  asthma with spleen deficiency  animal models  cAMP  cGMP
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