枸杞抗实验性高血脂肝脂量效关系及毒性研究 |
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引用本文: | 王德山,肖玉芳.枸杞抗实验性高血脂肝脂量效关系及毒性研究[J].辽宁中医杂志,1997,24(12):567-568. |
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作者姓名: | 王德山 肖玉芳 |
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作者单位: | 辽宁中医学院,沈阳市第十人民医院,辽宁中医学院附属医院 |
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摘 要: | 为了探讨枸杞子液降血脂及肝脂作用的量效关系,以及其毒性反应。分别用1g/kg、2g/kg、4g/kg枸杞子水煎液给实验性高脂血症大鼠灌胃10天,结果表明:不同剂量枸杞子液均有降低血中TC、TG、LDL-C的作用以及降低肝内TC、TG的作用。并且存在着明显的量效关系。即适当增大枸杞子液剂量可增强对实验性高脂血症大鼠血脂及肝脂的降脂作用,但对血细胞、肝功能及肾功能未见有不良影响。其调脂机制与影响外源性脂质代谢、肝脏脂质代谢有关。
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关 键 词: | 枸杞子液 高脂血症 肝内脂质 量效关系 毒性反应 |
Study on the toxic of Fructus Lycii on dose-effect relationship of anti-experimental hyperlipemia and hepatic lipid |
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Abstract: | In order to study the dose-effect relationship of Lyciuim against serum lipid and hepatic lipid,we give Lyciuim of 1g/kg,2g/kg,4g/kg seperately to experimental hyperlipemia mouse by oral taking for 10 days.The result show:Different dose of Lyciuim all have effect on lowering serum TC,TG,LDL-C and hepatic TC,TG,and there is obvious dose-effect relationship.That is,the more dose of Lyciuim the stronger effect on lowering experimental hyperlipemia and hepatic lipid.Its mechanism has relationship with affecting lipid metabolism and hepatic lipid metabolism. |
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Keywords: | dose-effect relationship\ experimental hyperlipemia\ hepatic lipid Lyciuim Barbarum L |
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