枣花丹合剂对失眠症夜间慢波睡眠影响的研究

目的:观察枣花丹合剂对失眠症夜间慢波睡眠的影响。方法:选择无器质性病变,每天睡眠少于240~300min为主症者64例患者随机分为两组。枣花丹合剂组在08:00和19:00时分别服用枣花丹合剂200mL。对照组在08:00和19:00时服同量红糖水,连服4周。睡眠监测的数据包括记录时间、非快动眼睡眠期、快动眼睡眠期、睡眠时间、觉醒时间、睡眠比、觉醒比。结果:枣花丹合剂组与对照组相比,夜间睡眠Ⅰ、Ⅱ期减少,Ⅲ、Ⅳ期增加;夜间觉醒次数减少,总睡眠时间明显增加;SWS睡眠结构比改变,SWS睡眠的连续性好、周期性显著,明显优于对照组改变,差异有统计学意义(P<0.05)。结论:枣花丹合剂可以增加失眠症夜间慢波睡眠,是治疗失眠症的一种有效和较好治疗方法。

The Effect of Cong Gan lun Zhi Liquor on Nocturnal Slow Wave Sleep with Insomnia

Objective:To evaluate the efficacy of treatment of zaohuadan liquor(ZHDL) on nocturnal slow wave sleep with insomnia.Methods:64 patients were randomly divided into two groups who taken poor sleep below 240~300 min per day without organic syndromes according to Pittsburgh Sleep Quality Index.We examined data of polysomnocinematograph(DPSG) before and after treatment as index for effects(data of polysomnocinematograph included time of record,non-rapid eye sleep,rapid eye sleep,time of sleep,time of wake,rate of sleep,rate of disenchantment).Each 200ml zaohuadan liquor drank in group of treatment and equal quantity water of black surge drank in controlled group at 08:00 and 19:00 for 28 days.Results:Nocturnal sleep I,II decreased and III,IV increased.nocturnal wakeful times decreased and total time of sleep significantly increased.Continuance and cycle of SWS was significant.Difference of DPSG in treated group compared with those of control group was significant(P<0.05).Conclusion:Zaohuadan liquor could increase nocturnal slow wave sleep with insomnia and was a better effective method treated in insomnia.