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糖尿病模型大鼠证候的特征及演变
引用本文:刘小美,方肇勤,卢文丽,潘志强,舒适.糖尿病模型大鼠证候的特征及演变[J].辽宁中医杂志,2008,35(1):130-134.
作者姓名:刘小美  方肇勤  卢文丽  潘志强  舒适
作者单位:上海中医药大学基础医学院,上海,201203
基金项目:上海市科委资助项目,上海市卫生局资助项目,上海市高校优秀青年教师后备人选科研项目
摘    要:目的:观察糖尿病(diabetes mellitus,DM)模型大鼠证候的发生与演变。方法:采用链脲佐菌素(STZ)腹腔注射,或结合高脂饲料喂养形成糖尿病模型,根据血糖诊断为隐性DM大鼠、2型DM大鼠、1型DM大鼠;同步检测体重、饮水、摄食、腋温、心率、爪、尾显微放大拍照及图像处理得到γ值、旷场水平跨格数和垂直站立数、抓力,求出正常对照组各指标均数,及各组的各动物实测值与正常对照组均数的比值,制定阴虚程度、阳气程度及胃热程度等计量辨证方法,对各组四诊进行比较。结果:1型DM大鼠成模后证候迅速发展为胃热、阴虚证候,并持续加剧、严重,早期见有阳气旺盛,以后逐渐发展至阳虚、气虚证,出现阴虚胃热兼气虚、阳虚证。2型DM成模后逐渐发展为胃热、阴虚证候,并持续加剧,程度轻于1型DM;成模早期有阳气旺盛倾向,以后逐渐向阳虚、气虚证过渡,但程度轻,不典型。隐性DM有轻度的胃热证候,且主要表现为饮水增加,其余证候不明显。结论:糖尿病大鼠存在特殊的证候、兼证,及其演变规律,其证候的严重程度是可以定量的,因而本研究对于糖尿病模型大鼠辨证论治治法的确定和评价奠定了基础。

关 键 词:糖尿病  链脲佐菌素  大鼠  证候  辨证
文章编号:1000-1719(2008)01-0130-05
收稿时间:2007-08-03
修稿时间:2007年8月3日

Characteristic and Development of Syndrome about Diabetes Mellitus Rats
LIU Xiao-mei,FANG Zhao-qin,LU Wen-li,PAN Zhi-qiang,SHU Shi.Characteristic and Development of Syndrome about Diabetes Mellitus Rats[J].Liaoning Journal of Traditional Chinese Medicine,2008,35(1):130-134.
Authors:LIU Xiao-mei  FANG Zhao-qin  LU Wen-li  PAN Zhi-qiang  SHU Shi
Abstract:Objectives:To observe the characteristic and development of syndrome about diabetes mellitus(DM) rats.Methods:Rats were modeled by intraperitoneal injection with streptozotocin(STZ),some taking high fat diet.Diagnosed as recessive DM rats,type 2 DM rats,type 1 DM rats according glucose density.Detect synchronously weight,water-drink,feed-ingest,oxter-temperature,heart rate,claw and tail photo in microscope which get r after image manipulation,open-field test to count level grille numbers and vertical stand numbers,grasp-force.Go out average of per index of normal control group,calculate the ratio:actual value of per rat to average of normal control group.Formulate the syndrome differentiation method of yin asthenia degree,yangqi degree and gastric heat degree,then compare the datas got by four diagnostic methods.Result:After modeled three days,syndrome of type 1 DM rat develop immediately as gastric heat,yin asthenia,and keep on intensifying.From yangqi prosperity in the nonage to yang asthenia or qi asthenia gradually,some with yin asthenia and gastric heat.type 2 DM rats after modeled well develop as gastric heat,yin asthenia gradually and intensify,but the degree of these syndrome is lighter than these of type 1 DM rats.type 2 DM rats have the tendency of yangqi prosperity in the nonage,then translate to yang asthenia and qi,as thenia,but these syndromes are slight and not typical.Recessive DM rats only have light gastric heat,syndromes are not obvious besides water-drink increasing.Conclusion:DM rats exist special syndromes,accompanied syndromes which have regularity of development.The degree of syndromes can be quantitated.The research established basis for the determination and evaluation of syndrome differentiation methods about DM rats.
Keywords:diabetes mellitus  streptozotocin  rats  syndrome  syndrome differentiation
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