胃食管反流病合并幽门螺杆菌感染的中医临床研究

目的:探讨Hp感染与胃食管反流病患者临床症状、食管炎症程度及中医证型分布的关系;根除Hp对胃食管反流病合并Hp感染中医临床疗效的影响。方法:回顾性调查胃食管反流病专科病例975例,比较Hp感染患者与无Hp感染患者在临床症状、食管炎症程度、中医证型分布方面的差异。将感染Hp的胃食管反流病患者分为根除组与未根除组,比较其中药辨证论治干预后的临床疗效。结果:975例胃食管反流病患者,合并Hp感染415例,感染率为42.56%;胃食管反流病合并Hp感染者与无Hp感染者临床症状、食管炎症程度均无显著性差异,合并Hp感染的胃食管反流病患者Barrett食管发病率较低与无Hp感染患者相比有显著性差异;GERD合并Hp感染患者中肝胃郁热证分布较多,中虚气逆证分布较少,与Hp阴性患者相比有显著性差异,且GERD合并Hp感染患者中未根除组烧心的表现少于Hp根除组;中医药辨证治疗合并Hp感染的胃食管反流病患者,根除组有效率为98.19%,未根除组为94.44%,两组间无显著性差异。结论:Hp感染对胃食管反流病患者临床症状、食管炎症程度无影响,胃食管反流病合并Hp感染患者中肝胃郁热证较多,中虚气逆证较少。中医药能够明显改善胃食管反流病患者的临床症状,与是否根除Hp无明显影响。

Study on Gastroesophageal Reflux Disease with Helicobacter Pylori Infection with Chinese Medicine

Objective:To investigate the relationship among the symptoms,inflammation degree and the distribution with TCM syndrome type in patients with gastroesophageal reflux disease and Helicobacter pylori infection,and evaluate Chinese medicine clinical effect on gastroesophageal reflux disease with Helicobacter pylori eradicated.Methods:The study was a retrospective survey and 975 patients with GERD were enrolled.The differences among the synmploms,inflammation degrees and the distribution with TCM syndrome type in GERD patients with and without Hp infection were compared,meanwhile GERD with Hp infection were also divided into two groups:one was Hp eradicated group,the other was non-Hp eradicated group,the efficiency of treatment with TCM was also observd.Results:There were 415 cases of Hp infection,the infection rate was 42.56%;clinical symptoms,esophageal inflammation degree in patients with or without Hp infection had no statistical significance,the incidenit of Barrett esophageal in patients with Hp infection were lower than that in patients with no Hp infection and also had statistical significance.Ganwei Yure syndrome is much more than Zhongxu Qini syndrome in patients with GERD and Hp infection,and also had statistical significance.The patients with GERD and not eradicate Hp heartburn was less than Hp eradicate group,the effective rate of treatment with TCM on the patients with gastroesophageal reflux disease and Hp infection was 98.19%,not eradicate group was 94.44%,between the two groups there was no statistical significance.Conclusion:Gastroesophageal reflux disease with Hp infection has no influence on clinical symptoms,esophageal inflammation degree.Ganwei Yure syndrome is much more than Zhongxu Qini syndrome in patients with GERD and Hp infection.Traditional Chinese medicine can significantly improve clinical symptoms of gastroesophageal reflux disease,and there was no significant effect on Hp eradication.