高血压不同并发症患者CRP、IL-6水平变化及血脂康干预的疗效观察

目的:观察原发性高血压(EH)不同合并症患者体内炎症反应的程度与中药血脂康的干预疗效。方法:观察EH患者120例,根据其合并症的不同,分为单纯EH组30例,EH合并心房颤动(EH-AF)组30例,EH合并腔隙性脑梗死(EH-LI)组30例,EH合并左心室肥厚(EH-LVH)组30例,同时选择30例健康体检者作为对照组。每组EH患者随机又分为两个亚组,即常规治疗亚组(主要运用钙拮抗剂ACEI、ARB、利尿剂、β受体阻断剂等药物治疗8周)和血脂康干预亚组(常规治疗加血脂康1.2g/d)。药物治疗前后检测血hs-CRP、IL-6水平。结果:(1)所有入选EH患者的hs-CRP、IL-6水平显著高于正常对照组(P<0.05);(2)EH-AF组、EH-LI组、EH-LVH组的hs-CRP、IL-6水平无明显差异(P>0.05),但均显著高于单纯EH组(P<0.05);(3)血脂康组和常规治疗组治疗后,其hs-CRP、IL-6水平均显著下降(P<0.05),两组间比较,血脂康组明显更优(P<0.05);(4)血脂康组和常规治疗组治疗后,其血压均显著下降(P<0.05),两组间比较,血脂康组的血压下降幅度更加显著(P<0.05)。结论:炎症反应指标hs-CRP、IL-6的上升与EH并发症的产生关系密切,血脂康能够显著下调EH患者的hs-CRP、IL-6和血压水平,提示联合应用降压药物和血脂康对于EH患者可能更为有益。

Observation on the Intervention Efficacy of Xuezhikang Capsule on Levels of CRP and IL-6 in Hypertension Patients with Different Complications

Objective:To observe the extent of inflammatory response in vivo in essential hypertension(EH)patients with different complications,and the intervention efficacy of Xuezhikang capsule.Methods:120 patients with EH were divided into 4 groups according to different complications:the EH group(n=30),the EH with atrial fibrillation(EH-AF)group(n=30),the EH with lacunar infarction(EH-LI)group(n=30)and the EH with left ventricular hypertrophy(EH-LVH)group(n=30).Meanwhile,30 healthy subjects were served as the control group.The each group of EH patients were randomly divided into the conventional treatment subgroup(calcium antagonists,ACE inhibitors,ARB,diuretics and beta-blocker treatment for 8 weeks)and the Xuezhikang intervention subgroup(Xuezhikang capsule,1.2g/d,and conventional treatment for 8 weeks).The levels of serum hs-CRP and IL-6 were determined before and 8 weeks after the treatment.Results:(1)The levels of hs-CRP and IL-6 in EH,EH-AF,EH-LI and EH-LVH groups were superior to that in control group(P<0.05).(2)There was no statistically significant difference among the four groups with EH(P>0.05).(3)After 8 weeks of treatment,the levels of hs-CRP and IL-6 decreased(P<0.05),and the efficacy of Xuezhikang intervention subgroup was superior to that of conventional treatment subgroup(P<0.05).(4)Similarly,the levels of blood pressure decreased after treatment(P<0.05),and the efficacy of Xuezhikang intervention subgroup was also superior to that of conventional treatment subgroup(P<0.05).Conclusion:The indicators of inflammatory response such as hs-CRP and IL-6 have a close relationship with EH complications.Xuezhikang could markedly decrease the levels of hs-CRP and IL-6 and blood pressure.It is prompted us that the joint application of antihypertensive drugs and Xuezhikang may be more useful to EH patients.