乙肝肝胆湿热证与血清HA等的相关性研究

观察乙型病毒性肝炎肝胆湿热证与血清 HA、TNF- α、IL- 6水平的相关性。乙型病毒性肝炎12 2例 ,辨证分为肝胆湿热证、肝郁脾虚证、肝脾血瘀证和肝肾阴虚证 ,放免双抗体法和 EL ISA法分别测定血清 HA、TNF- α、IL- 6水平。结果 ,肝胆湿热证多见血清 HA、TNF- α、IL- 6水平升高 ,且与 AL T的变化规律一致 ;肝郁脾虚证 ,三者的变化不明显 ;肝脾血瘀证和肝肾阴虚证 ,以 HA升高为主 ,TNF- α、IL- 6的变化不显著。乙型病毒性肝炎患者血清 HA、TNF- α、IL- 6水平升高 ,可为肝胆湿热证的中医辨证提供客观依据

Correlation Research on Serum Level of HA、TNF-α、IL-6 with Liver and Gallbladder Wetness-heat Syndrome of Hepatitis B

To observe correlation of serum level of HA、TNF α、IL 6 with Liver and Gallbladder Wetness-heat Syndrome in hepatitis B patients.Methods:120 hepatitis B patients were diagnozed as Liver and Gallbladder Wetness-heat Syndrome,GanYu PiXu Zheng,GanPi XueYu Zheng and GanShen YinXu Zheng;Serum level of HA、TNF α、IL 6 were determined by methods of biantibody radioimmunoassay and enzyme linked immunosorbent(ELISA).Results:In patients of Liver and Gallbladder Wetness-heat Syndrome serum level of HA、TNF α、IL 6 mostly rise and were consistent with variation of ALT;in GanYu PiXu Zheng,the change were not evident;in GanPi XueYu Zheng and GanShen YinXu Zheng,HA mostly rise,change of TNF α、IL 6 were not obvious.Conclusions:Serum level of HA、TNF α、IL 6 in hepatitis B patients administer to diagnosis of TCM.