冠心病痰浊证与血清低密度脂蛋白胆固醇相关性的Meta分析

目的:探讨冠状动脉粥样硬化性心脏病(冠心病,CHD)痰浊证与血清低密度脂蛋白胆固醇(LDL-C)的相关性,为CHD的中医辨证提供客观化参考依据。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学全文数据库、美国国立医学图书馆、国际性综合生物医学信息书目数据库等,收集建库至2019年5月公开发表的关于CHD中医证型与LDL-C相关性研究的文献,按纳入标准和排除标准完成文献筛选、资料提取和文献质量评价后,采用RevMan5.3软件对纳入研究进行Meta分析。结果:最终纳入文献19篇,共计2609例患者,痰浊证组血清LDL-C水平与正常对照组(MD=1.18,95%CI0.81,1.55],P<0.001)和非痰浊证组(MD=0.34,95%CI0.13,0.56],P=0.002)比较,差异均有统计学意义,提示痰浊证组血清LDL-C水平明显高于正常对照组及非痰浊证组。结论:血清LDL-C水平升高可作为CHD痰浊证诊断的客观参考指标。

Meta-Analysis on the Correlation Between Coronary Heart Disease of Phlegm Turbidity Syndrome and Serum Low Density Lipoprotein Cholesterol

Objective:To explore the correlation between coronary atherosclerotic heart disease(CHD)of phlegm turbidity syndrome and serum low density lipoprotein cholesterol(LDL-C),so as to provide an objective reference for traditional Chinese medicine(TCM)syndrome differentiation of CHD.Methods:Literatures on the correlation between TCM syndromes in CHD and LDL-C published were retrieved by searching CNKI,CBM,VIP,Wanfang,PubMed,Medline,and other databases from the inception to May 2019.After literatureswere selected according to the inclusion and exclusion criteria,the data were extracted,and the quality of the literatures was evaluated,Meta-analysis was performed with Rev Man 5.3.Results:Finally,19 literatures were included,with a total of 2609 patients.The levels of LDL-C in the phlegm turbidity syndrome group were statistically different from thatin the normal control group(MD=1.18,95%CI0.81,1.55],P<0.001)and the non-phlegm turbidity syndrome group(MD=0.34,95%CI0.13,0.56],P=0.002).The result indicated that the level of LDL-C in the phlegm turbidity syndrome group was significantly higher than that in the normal control group and the non-phlegm turbidity syndrome group.Conclusion:LDL-C of high level could be used as an objective index for the diagnosis of CHD of phlegm turbidity syndrome.