小柴胡汤加味联合西药治疗少阳失枢型2型糖尿病临床研究

目的:研究小柴胡汤加味联合西药治疗对少阳失枢型2型糖尿病(T2DM)患者临床症状、体质量指数(BMI)、血糖、血脂、炎性因子等指标的影响。方法:180例少阳失枢型T2DM患者按就诊顺序分为观察组和对照组各90例,研究中脱落8例,最终完成研究者172例,观察组87例,对照组85例。两组均进行健康教育、饮食控制、规律运动,对照组给予盐酸二甲双胍片和地特胰岛素治疗,观察组在对照组基础上给予经方小柴胡汤加味治疗,两组均以3个月为1个疗程,均治疗1个疗程,并随访6个月。比较两组治疗前、治疗后、治疗后6个月的中医症状分级量化情况,BMI,血糖、血脂变化,炎性因子,血清Hcy、纤维蛋白原水平,以及生活质量。结果:与治疗前比较,两组治疗后、治疗后6个月的中医症状分级量化、BMI、血糖、血脂、炎性因子、血清Hcy及纤维蛋白原水平、生活质量均改善,且观察组上述各指标改善均优于对照组,差异均有统计学意义(P0.05)。结论:小柴胡汤加味配合西药治疗能明显改善少阳失枢型T2DM患者的临床症状和胰岛功能,降低炎性因子表达,提高生活质量。

Clinical Study of Treating Type 2 Diabetes Mellitus of Shaoyang Disorder Syndrome by Modified Xiaochaihu Decoction Combined with Western Medicine

Objective:To study the effects of modified Xiaochaihu Decoction combined with western medicine on clinical symptoms,body mass index(BMI),blood glucose,blood lipid and inflammatory factors of patients with type 2 diabetes mellitus(T2 DM) of Shaoyang disorder syndrome. Methods:A total of 180 patients with T2 DM of Shaoyang disorder syndrome were divided into observation group and control group according to the time sequence of seeing doctor,with 90 cases in each group. Because 8 patients withdrew from the study,finally there were 172 cases completed this study,with 87 cases in the observation group and 85 cases in the control group. Health education,diet control and regular exercise were carried out in both groups. The control group was treated with metformin hydrochloride tables and detinsulin.On the basis of the control group,the observation group was treated with modified Xiaochaihu Decoction. For both groups,1 treatment course lasted for 3 months and 1 course of treatment was given to them.After treatment,the patients were followed for 6 months. Before treatment,after treatment and 6 months after treatment,indicators of the two groups including classification and quantification of traditional Chinese medicine symptoms,BMI,changes of blood glucose and lipid,inflammatory factors,levels of serum Hcy and fibrinogen,life quality were compared. Results:After treatment and 6 months after treatment,indicators of the two groups such as the classification and quantification of traditional Chinese medicine symptoms,BMI,blood glucose and lipid,inflammatory factors,levels of serum Hcy and fibrinogen,life quality were all improved,and the improvements of the observation group were better than those of the control group. The differences were statistically significant(P<0.05). Conclusions:Modified Xiaochaihu Decoction combined with western medicine treatment can significantly improve the clinical symptoms and islet function of patients with T2 MD of Shaoyang disorder syndrome,reduce the expression of inflammatory factors,and improve their life quality.