补肾化痰汤联合西药治疗生育期多囊卵巢综合征临床研究

目的:观察补肾化痰汤联合西药治疗生育期多囊卵巢综合征(PCOS)疗效。方法:选择符合入选标准的PCOS患者96例,随机分为观察组及对照组各48例。对照组周期性应用去氧孕烯炔雌醇片(妈富隆),观察组在对照组的基础上联合应用补肾化痰汤,两组患者均于月经周期结束后口服来曲唑促排卵治疗。治疗3个周期后观察两组患者用药前后体质量、体质量指数(BMI)、各生殖激素水平的变化及促排卵治疗后两组子宫内膜厚度、卵泡发育情况及排卵率、妊娠率的差异。结果:两组患者用药前后体质量、BMI、各生殖激素水平比较差异有统计学意义(P0.05),两组患者促排卵后子宫内膜厚度、优势卵泡率、排卵率及妊娠率等方面比较差异有统计学意义(P0.05)。结论:补肾化痰汤联合妈富隆、来曲唑治疗PCOS具有降低体质量、月经恢复正常、不良反应少、卵泡发育好、子宫内膜厚度适宜、排卵率和妊娠率高的效果。

Clinical Study of Polycystic Ovary Syndrome in Child-bearing Period Treated with Bushen Huatan Decoction Combined with Western Medicine

Objective:To observe the effect of polycystic ovary syndrome(PCOS) in child-bearing period treated with Bushen Huatan decoction combined with western medicine. Methods:There were 96 PCOS patients meeting with the criteria randomly divided into observation group and control group,48 cases in each group.The control group was given ethinyl estradiol periodically,while the control group was given Bushen Huatan decoction besides ethinyl estradiol. Patients in both groups after menstruation were given letrozole for ovulation induction. After treated for 3 periods,before and after treatment,the body weight,body mass index(BMI),the changes of reproductive hormones levels were observed. Also the difference between the two groups on endometrial thickness,percentage of dominant follicle,ovulation rate,pregnancy rate after ovulation induction were observed. Results:There were significant difference between before treatment and after treatment on body weight,BMI and reproductive hormones levels(P<0.05). There were statistical difference on endometrial thickness,percentage of dominant follicle,ovulation rate and pregnancy after ovulation induction between two groups(P<0.05). Conclusion :Bushen Huatan decoction in combination with ethinyl estradiol and letrozole for PCOS can reduce body weight and normalize menstruation with less side effects,well developed follicle,normal endometrial thickness and increased ovulation rate and pregnancy rate.