一效膏治疗糖尿病足临床研究

目的:研究一效膏治疗糖尿病足患者溃疡创面的临床疗效。方法:应用随机数字表法将108例糖尿病足溃疡患者随机分为治疗组54例和对照组54例。两组患者给予基础治疗后,治疗组予一效膏外用治疗,对照组予康复新液外用治疗。观察两组患者治疗前后足部症状评分(包括创面缩小率、肉芽组织填充率、坏死组织附着率、创面渗出、疼痛)、创面组织血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)水平变化,比较两组临床疗效及安全性。结果:治疗后,治疗组创面缩小率评分、肉芽组织填充率评分、坏死组织附着率评分、疼痛程度足部症状评分均低于对照组,差异有统计学意义(均P<0.05)。治疗后,治疗组创面组织VEGF、PDGF水平均高于对照组,差异有统计学意义(均P<0.05)。治疗组临床总有效率94.44%,高于对照组的77.78%,组间差异有统计学意义(P<0.05)。治疗期间,两组患者均未发生严重不良反应。结论:一效膏外用治疗糖尿病足溃疡,可明显改善足部症状评分,以及局部VEGF、PDGF水平,临床疗效较好。

Clinical study on Yixiao ointment in treating diabetic foot

Objective:To study the clinical effect of Yixiao ointment on ulcer wound of diabetic foot.Methods:108 patients with diabetic foot ulcer were randomly divided into 54 cases in treatment group and 54 cases in control group according to the digital table method.After basic treatment,the treatment group was treated with Yixiao ointment external treatment and the control group was treated with Kangfuxin liquid external treatment.The foot symptom score(including wound reduction rate,granulation tissue filling rate,necrotic tissue attachment rate,wound exudation,pain),changes in VEGF and PDGF levels in wound tissue,clinical efficacy and safety were compared.Results:The scores of foot symptoms in the treatment group were lower than those in the control group,including wound reduction rate,granulation tissue filling rate score,necrotic tissue attachment rate score,and pain score,difference statistically significant(all P<0.05).The expression of wound tissue VEGF and PDGF in the treatment group were higher than those in the control group,difference statistical significance(all P<0.05).After treatment,the clinical effective rate in the treatment group 94.44% was higher than that in the control group 77.78%,difference statistical significance(P<0.05). Both groups had no serious adverse reactions during the treatment.Conclusion:Yixiao ointment for external use in the treatment of diabetic foot ulcer can significantly improve the foot symptom score,local VEGF,PDGF expression level,clinical effect is good.