从脾论治慢性肾脏病的生物学基础探讨

脾为后天之源,肾为先天之本,以后天滋先天,使从脾论治成为中医临床治疗慢性肾脏病(CKD)的经典方法。现代医学研究发现人体内最庞大的“器官”——肠道菌群与“脾”的功能非常密切。目前研究发现肠道菌群紊乱是加速CKD进展的重要环节,基于脾肾互根互用的中医原理,收集、整理肠道菌群与CKD代谢功能、免疫应答及肾脏损伤关联的文献,从肠道菌群与机体功能代谢和内环境稳态的角度进行探讨,认识到运用中医药可通过干预肠道菌群的丰度、结构和代谢功能,维持肠道微生态的平衡,从而达到调节肾脏代谢和免疫应答的作用,提出肠道菌群是从脾论治慢性肾脏病的重要生物学基础。

Discuss the biological foundation for chronic disease therapy from treatment through the spleen

According to Chinese medicine theory the spleen is regarded as the root of after-birth and the kidney as the origin of the body.The treatment through the spleen has become a classic method in the clinical experience of chronic kidney disease(CKD)because the root of after-birth can nourish the origin.Modern research has found that the gut microbiota is the largest “organ” in the human body,which is closely related to the spleen at the same time.Current studies have found that there are some links between gut microbiota disorder and process of CKD acceleration.Based on the TCM principle of spleen and kidney mutual interaction,we are collecting and organizing the literature about gut microbiota,CKD metabolism function and immune response.After that we have realized that in the perspective of gut microbiota,body function metabolism and internal environment homeostasis,the Chinese medicine intervention could maintain the balance of gut microbiota through regulate the abundance,structure and metabolic function,then adjust the metabolism and immune response of kidney.It is suggested that gut microbiota is an important biological basis for the treatment of chronic kidney diseases from the spleen.