健脾益肾法治疗原发性肾病综合征疗效及对患者机体血液流变学、免疫学指标的影响

目的:探讨健脾益肾方法在原发性肾病综合征疾病中的治疗效果,并对机体血液流变学指标、血清免疫学指标的变化影响进行观察。方法:选择113例原发性肾病综合征患者,按照患者自愿治疗原则,将患者分为观察组与对照组,观察组57例,对照组56例。对照组患者采用西药治疗(甲泼尼龙片+灯盏注射液),观察组患者采用健脾益肾方剂治疗,7d为1个疗程,连续治疗14个疗程。观察两组患者的临床疗效及治疗前后血液流变学指标(全血黏度、血浆黏度、纤维蛋白原、红细胞变形指数)、血清免疫学指标(IL-8、IL-13、TGF-β、INF-γ)的变化。结果:(1)观察组与对照组的临床总有效率分别为94.74%(54/57)、83.93%(47/56),两组比较差异有统计学意义(P<0.05);(2)治疗前两组血液流变学指标变化比较差异无统计学意义(P>0.05),治疗后观察组全血黏度、血浆黏度、纤维蛋白原指标与对照组比较均明显降低(P<0.05),红细胞变形指数比较差异无统计学意义(P>0.05);(3)治疗前比较两组血清免疫学指标均无统计学意义(P>0.05),治疗后IL-8、TGF-β、INF-γ与对照组比较降低(P<0.05),IL-13与对照组比较升高(P<0.05)。结论:健脾益肾方剂对原发性肾病综合征患者具有较好的治疗效果,有效改善临床症状,在改善机体血液黏稠度,免疫学指标因素方面比西药治疗效果更加显著。

Effect of spleen and kidney method in patients with primary nephrotic syndrome and its influence on body blood rheology and immunological indicators

Objective:To investigate the therapeutic effect of the method of invigorating the spleen and invigorating the kidney in patients with primary nephrotic syndrome and to observe the influence of the indexes of blood rheology and serum immunological indexes.Methods:113 patients with primary nephrotic syndrome were divided into the observation group(57cases)and the control group(56cases)according to the principle of voluntary treatment.The patients in the control group were treated with western medicine(methylprednisolone tablets and Dengzhan injection).The patients in the observation group were treated with the recipe of invigorating spleen and kidney,and the7days were as a course of treatment,and last for14courses of continuous treatment.The clinical curative effect and the changes of indexes of hemorheology(whole blood viscosity,plasma viscosity,fibrinogen,erythrocyte deformability index),serum immunological indexes(IL-8,IL-13,INF-γ)of the two groups were observed.Results:①The total effective rates of the observation group and the control group were 94.74%(54/57)and 83.93%(47/56),and there were with significant differences between the two groups(P<0.05).②There were no significant differences in rheological indexes before treatment(P>0.05).After treatment,the whole blood viscosity,plasma viscosity and fibrinogen index of the observation group were significantly lower than those of the control group(P<0.05),the differences of erythrocyte deformity index were withoutstatistical significance(P>0.05).③The serum immunological indexes of the two groups were without significant differences before treatment(P>0.05).After treatment,the levels of IL-8,TGF-βand INF-γwere decreased compared with the control group(P<0.05),while the levels of IL-13and control group were increased(P<0.05).Conclusion:Spleen and kidney recipe has a better therapeutic effect on patients with primary nephritic syndrome and effectively improves clinical symptoms.It is more effective than western medicine in improving blood viscosity and immunological parameters.