补肾活血汤对小卵泡排卵不孕症患者卵泡发育、卵巢动脉血流的影响

目的:观察补肾活血汤对小卵泡排卵(SFO)不孕症患者卵泡发育、卵巢动脉血流的影响。方法:将80例SFO不孕症患者随机分为两组,对照组40例接受枸橼酸氯米芬口服治疗,观察组40例,在对照组基础上加用补肾活血汤治疗,两组均治疗3个月经周期。统计两组临床疗效,并比较两组最大卵泡平均直径、子宫内膜厚度、成熟卵泡排卵率、未破裂卵泡黄素化综合征(LUFS)、妊娠率、早期自然流产率、性激素与卵巢动脉血流。结果:观察组治疗的临床总有效率为82.50%,明显高于对照组的62.50%(P<0.05)。与治疗前比较,两组治疗后最大卵泡平均直径、子宫内膜厚度均明显增加(P<0.05),且治疗后观察组以上指标均高于对照组(P<0.05)。观察组成熟卵泡排卵率和妊娠率高于对照组(P<0.05),LUFS发生率、早期自然流产率低于对照组(P<0.05)。与治疗前比较,治疗后两组血清LH、E₂水平、卵巢动脉PSV、EDV均明显增加(P<0.05),血清FSH、RI均明显降低(P<0.05),且治疗后观察组上述指标均优于对照组(P<0.05)。结论:补肾活血汤可明显促进SFO不孕症患者卵泡发育,增加成熟卵泡排卵率与妊娠率,并改善性激素与卵巢动脉血流循环。

Effect of Bushen Huoxue decoction on follicular development and ovarian artery blood flow in infertile patients with small follicle ovulation

Objective:To observe the effect of Bushen Huoxue decoction on follicular development and ovarian artery blood flow in infertile patients with small follicle ovulation(SFO).Methods:80 cases of infertility caused by SFO were randomly divided into two groups.40 cases in the control group were treated with clomiphene citrate orally,40 cases in the observation group were treated with Bushen Huoxue decoction on the basis of the control group.The mean diameter of the largest follicle,endometrial thickness,ovulation rate of mature follicle,luteinized unruptured follicle syndrome(LUFS),pregnancy rate,early spontaneous abortion rate,sex hormone and ovarian artery blood flow were compared.Results:the total clinical effective rate of the observation group was 82.50%,which was significantly higher than that of the control group 62.50%(P<0.05).After treatment,the mean diameter of the largest follicle and the thickness of endometrium in the two groups were significantly increased(P<0.05),and the above indexes in the observation group were higher than those in the control group(P<0.05).The ovulation rate and pregnancy rate of mature follicles in the observation group were higher than those in the control group(P<0.05),and the incidence of LUFS and early spontaneous abortion were lower than those in the control group(P<0.05).Compared with before treatment,the levels of serum LH,E₂,PSV and EDV of ovarian artery in the two groups were significantly increased(P<0.05),FSH and RI were significantly reduced(P<0.05),and the above indexes in the observation group were better than those in the control group(P<0.05).Conclusion:Bushen Huoxue decoction can obviously promote the follicular development,increase the ovulation rate and pregnancy rate of mature follicles,and improve the sexual hormone and ovarian artery blood circulation in patients with SFO and infertility.