黃芩和黄芪代替抗生素根除幽门螺杆菌的临床研究

目的探讨中药代替抗生素根除幽门螺杆菌(H.pylori)的临床疗效和应用价值。方法选择慢性胃炎有上消化道症状、1个月内未用过抗生素或抑酸药、14C呼气试验H.pylori阳性患者240例,随机分为3组:A组80例给予黄芩和黄芪(生药各10 g)制成的颗粒剂,每日1剂,用开水50 mL冲调,分2次餐前口服,连续1周;B组80例在A组基础上同时口服埃索美拉唑20 mg,每日2次,连续1周;C组80例予阿莫西林1.0 g、克拉霉素0.5 g、埃索美拉唑20 mg口服,每日2次,连续1周。3组均停药4周后复查14C呼气试验,H.pylori阴性为根除。结果 A组、B组、C组的H.pylori根除率分别为70%,93%和90%。结论黄芩和黄芪代替抗生素联合埃索美拉唑能有效根除H.pylori,是一种新的理想的H.pylori根除方案。

Clinical study of Baicalensis and Astragalus replace antibiotics for eradication of Helicobacter pylori

objective It is to explore the clinical curative effect and application value of Baicalensis and Astragalus replace antibiotics for eradication of Helicobacter pylori(H.pylori).Methods A total number of 240 14C-UBT Hp-positive chronic gastritis patients with upper gastrointestinal symptoms who didn't take any antibiotics or acid-suppressing drugs within one month were collected,and were randomly divided into three groups: 80 cases of group A received therapy with oral Baicalensis and Astragalus and at a dosage of 10 g dissolved with 50 mL boiling water for 2 times in each day before dining.80 cases of group B received continuous therapy on the basis of the former group with oral esomeprazole 20 mg for 2 times in each day for one week.80 cases of group C received amoxicillin 1.0 mg,clarithromycin 0.5 mg and esomeprazole 20 mg for 2 times in each day for one week.H.pylori infection was detected by 14C-urea breath test in a minimum of 4 weeks after therapy.Eradication of H.pylori was diagnosed when the test results were negative.Results The eradication rates of H.pylori group A,group B and group C were 70%,93% and 90 respectively.Conclusion Baicalensis and Astragalus combined with esomeprazole can effectively eradicate H.pylori,and this method is a new and perfect therapy for Hp infection.