高血压病靶器官损害与中医证型相关性研究

目的探讨原发性高血压病不同中医证型与靶器官损害的相关性。方法选择176例原发性高血压患者经中医辨证分为四型:肝火亢盛26例,阴虚阳亢51例,痰湿壅盛54例,阴阳两虚45例;选取正常健康者20例作为对照组。对各组肌酐、24 h尿蛋白定量、超声心动图及颈动脉内中膜厚度(IMT)等高血压靶器官损害进行相关性研究。结果①痰浊中阻证IMT及斑块数量较其他三组高,且有显著性差异。②阴阳两虚证左心室肥厚发病率较其他三组高,且有显著性差异。③阴阳两虚证血肌酐及24 h尿白蛋白定量均较其他三组高,且有显著性差异。结论①高血压病伴动脉粥样硬化性疾病可作为痰浊中阻证辨证的参考指标。②血肌酐及24 h尿白蛋白定量可作为阴阳两虚证辨证的客观化指标。③高血压病伴充血性心力衰竭可作为阴阳两虚证辨证的参考指标。

Correlation study on target organ damage and TCM syndrome type in patients with hypertension

Objective It is to approach thecorrelation between target organ damage(TOD) and TCM Syndrome Type in patients with essential hypertension(EH).Methods 176 patients with essential hypertension were divided into 4 type by TCM syndrome type:26 cases with liver-fire hyperactivity type,51 cases with yin deficiency and yang hyperactivity type,54 cases with excessive phlegm-dampness type and 45 cases with yin-yang deficiency type.20 cases of normal people were selected for control.The indexes of TOD as SCr,quantitative test for urinary protein in 24-hour,ultrasoundcardiogram and carotid intima-media thickness(IMT) in patients with EH were detected and used to analyze the correlation.Results ①The IMT and plaque number in the syndrome of excessive phlegm-dampness were higher than that in the other groups,the differences were significant.②The incidence of left ventricular hypertrophy(LVH) in the syndrome of yin-yang deficiency was higher than that in the other groups,the differences were significant.③The levels of SCr and UEA in the syndrome of yin-yang deficiency were higher than that in the other groups,the differences were significant.Conclusion ①EH with atherosclerosis can be applied as the subjective index for the syndrome of excessive phlegm-dampness.②The increase of SCr or UEA can be applied as the subjective index for the syndrome of yin-yang deficiency.③EH with CHF can be applied as the subjective index for the syndrome of yin-yang deficiency.