抗炎合剂在早期脓毒症患者中的治疗作用

目的观察中药抗炎合剂治疗早期脓毒症患者的疗效。方法 61例早期脓毒症患者随机分为治疗组和对照组,对照组30例予常规治疗,治疗组31例在对照组基础上加用抗炎合剂。观察治疗前后APACHEⅡ评分,比较治疗前后不同时段血乳酸、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、血小板及D-二聚体的变化,随访28 d病死率。结果 2组治疗后APACHEⅡ评分均下降(P均<0.05),治疗组优于对照组(P<0.05)。治疗3 d后治疗组血乳酸水平下降(P<0.05),优于对照组(P<0.05);CRP治疗组下降明显(P<0.05);血小板对照组下降明显(P<0.05)。治疗7 d后,2组乳酸水平均恢复正常(P均<0.01),组间比较无显著性差异;TNF-α2组均下降(P均<0.05),治疗组下降更明显(P<0.05);CRP治疗组下降显著(P<0.01),优于对照组(P<0.05);对照组Plt下降持续,治疗组较对照组有一定程度恢复(P<0.05);D-二聚体对照组明显上升(P<0.05)。28 d病死率2组比较无显著性差异。结论抗炎合剂治疗早期脓毒症患者有效。

Curative effect of anti inflammatory agent on prophase of sepsis

Objective It is to observe the curative effect of anti-inflammatory agent on prophase of sepsis.Methods Sixty-one patients with prophase of sepsis were randomly divided into two groups.Thirty patients were in control group and treated with conventional treatment.Thirty-one patients were in treatment group and treated with anti-inflammatory agent based on the treatment of control group.The APACHE Ⅱ scores before and after treatment were observed.The changes of blood lactic acid,TNF-α,CRP,Plt and D-dimer before and after treatment in different time slots were compared.The 28 d fatality rate was followed up.Results The APACHE II scores in the two groups both lowered after treatment(both P<0.05) and the treatment group was superior to the control group(P<0.05).The level of blood lactic acid in treatment group lowered after treatment for 3 d(P<0.05) and the treatment group was superior to the control group(P<0.05).The level of CRP in treatment group lowered obviously(P<0.05) and the level of Plt in control group lowered obviously(P<0.05).After treatment for 7 d,the level of blood lactic acid in the two groups both restored to normal(both P<0.01) and the difference was no significance between the two groups.The level of TNF-α in the two groups both lowered(both P<0.05) and that in treatment group lowered more obviously(P<0.05).The level of CRP in treatment group lowered significantly(P<0.01) and was superior to the control group(P<0.05).The level of Plt in control group lowered continuously and that in treatment group restored to a certain level(P<0.05).The level of D-dimer in control group heightened obviously(P<0.05).The difference on the 28 d fatality rate was no significant between the two groups.Conclusion It is effective of anti-inflammatory agent on prophase of sepsis.