| 头针对脑缺血大鼠唾液酸-神经细胞黏附分子表达的影响 |
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| 引用本文： | 张晓艳,张红星,邹燃,黄国付,王琼,刘银妮.头针对脑缺血大鼠唾液酸-神经细胞黏附分子表达的影响[J].现代中西医结合杂志,2011,20(13):1581-1582,1585. |
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| 作者姓名： | 张晓艳 张红星 邹燃 黄国付 王琼 刘银妮 |
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| 作者单位： | 1. 湖北中医药大学,湖北武汉,430065
2. 湖北省武汉市中西医结合医院,湖北武汉,430022 |
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| 摘 要： | 目的研究头针对脑缺血再灌注大鼠唾液酸-神经细胞黏附分子(PSA-NCAM)表达的影响,探讨头针治疗脑缺血病的作用机制。方法采用线栓法制作成大脑中动脉闭阻(MCAO)模型,各组大鼠又按照缺血时间(7 d、14 d、28 d)分为3个亚组,每个时相点10只。头针组动物于栓塞再灌注成功后即行头针治疗,每日1次,直至处死前。各组大鼠处死前1d腹腔注射5-溴脱氧尿核苷(B rdU)液。对各亚组大鼠行神经功能缺损评分(NSS),免疫荧光法计数各组大鼠海马区(DG)B rdU/PSA-NCAM阳性双标细胞。结果第28天头针组的NSS显著低于模型组(P<0.05)。大鼠在缺血再灌注后PSA-NCAM阳性细胞有明显表达,而头针组在不同时相的阳性细胞数量较同时相模型组有明显增加。结论头针能促进B rdU/PSA-NCAM的表达,从而可能诱导神经干细胞(NSCs)的迁移,并能在一定程度上改善神经功能缺损,实现保护脑组织的目的。
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| 关 键 词： | 脑缺血 神经干细胞 头针 唾液酸-神经细胞黏附分子 |
Effect of scalp-acupuncture on expression of PSA-NCAM in acute cerebral ischemia rats |
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| Zhang Xiaoyan,Zhang Hongxing,Zou Ran,Huang Guofu,Wang Qiong,Liu Yinni.Effect of scalp-acupuncture on expression of PSA-NCAM in acute cerebral ischemia rats[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2011,20(13):1581-1582,1585. |
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| Authors: | Zhang Xiaoyan Zhang Hongxing Zou Ran Huang Guofu Wang Qiong Liu Yinni |
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| Institution: | Zhang Xiaoyan1,Zhang Hongxing2,Zou Ran2,Huang Guofu2,Wang Qiong1,Liu Yinni1(1.Hubei University of Traditional Chinese Medicine,Wuhan 430065,Hubei,China,2.Wuhan Chinese and Western Medicine Hospital,Wuhan 430022,China) |
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| Abstract: | Objective It is to research the effect of scalp-acupuncture(SA) on expression of(polysialylated neural cell adhesion molecule,PSA-NCAM) in acute cerebral ischemia/reperfusion injury rats,and to explore the mechanisms of SA in treating for cerebral ischemia.Methods Models of middle cerebral artery occlusion(MCAO) were established by line ligation method,and the models were divided into 3sets respectively according to ischemic time(7 d,14 d,28 d),and each set was 10.SA rats were treated after MCAO experiments... |
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| Keywords: | cerebral Ischemia neural stem cell scalp-acupuncture PSA-NCAM |
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