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降脂护肝方对高脂饮食诱导脂肪肝大鼠的影响
引用本文:林路平,肖会泉,连粤湘,姚细安,李晓霞.降脂护肝方对高脂饮食诱导脂肪肝大鼠的影响[J].现代中西医结合杂志,2009,18(29):3547-3549.
作者姓名:林路平  肖会泉  连粤湘  姚细安  李晓霞
作者单位:1. 广东省广州市第八人民医院,广东,广州,510060
2. 广州中医药大学第一附属医院,广东,广州,510000
基金项目:广东省广州市卫生局资助项目 
摘    要:目的探讨降脂护肝方对非酒精性脂肪肝(NAFL)大鼠的药效作用。方法采用高脂饮食复制NAFL大鼠。造模2周后随机分为模型组、降脂护肝方(大、中、小剂量)组、血脂康组。用药后,观察一般情况及肝功能、血脂,并进行肝脏病理检查。结果模型组肝组织出现严重的大疱样脂肪变性,肝脏炎症表现明显;降脂护肝方组的上述改变显著减轻,同时可显著降低体质量、肝指数以及血清ALT、AST、TG、TC,与模型组比较均有显著性差异(P均<0.05)。结论降脂护肝方对高脂饮食诱导的NAFL及其炎症有较理想的防治作用。

关 键 词:降脂护肝方  非酒精性脂肪肝  中医药疗法

Influence of Jiangzhihugan decoction on fatty liver of rats induced by high fat diet
Lin Luping,Xiao Huiquan,Lian Yuexiang,Yao Xi'an,Li Xiaoxia.Influence of Jiangzhihugan decoction on fatty liver of rats induced by high fat diet[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2009,18(29):3547-3549.
Authors:Lin Luping  Xiao Huiquan  Lian Yuexiang  Yao Xi'an  Li Xiaoxia
Abstract:Objective It is to approach the drug action of Jiangzhihugan decoction on nonacohol fatty liver(NAFL) rats.Methods NAFL rat models were established with high fat diet.After the models were established for two weeks,the rats were randomly divided into model group,Jiangzhihugan decoction high dose group and Jiangzhihugan decoction medium dose group,Jiangzhihugan decoction low dose group and Xuezhikang group.After treatment,the general situation,liver function,blood lipid and liver biopsy were observed.Results There was serious fatty degeneration in liver tissue in model group and liver inflammation displayed obviously.The above changes in Jiangzhihugan decoction groups lightened significantly and could significantly lower the body mass,liver index and serum ALT,AST,TG,TC.There was significant difference compared with control group(P<0.05).Conclusion Jiangzhihugan decoction has desirabler preventive and therapeutic effect on NAFL induced by high fat diet and its inflammation.
Keywords:Jiangzhihugan decoction  nonacohol fatty liver  traditional Chinese medical therapy
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