丹参多酚酸盐对血小板功能影响的临床研究

目的探讨丹参多酚酸盐对血小板功能的影响以及治疗稳定型心绞痛的临床疗效。方法将56例稳定型心绞痛患者随机分为丹参多酚酸盐低剂量组(A组)、高剂量组(B组)和丹参注射液对照组(C组),均治疗14d,观察3组的症状缓解、平板试验改善情况以及血小板聚集率、P选择素变化情况。结果A组和B组在降低血小板聚集率和P选择素方面优于C组,在症状缓解、平板试验改善方面与C组相近。结论丹参多酚酸盐能明显抑制血小板的聚集和活化,改善心绞痛症状及平板试验心电图ST—T变化。

Influence study of depside salt from salvia miltiorrhiza on blood platelet function

Objective It is to study the influence of depside salt from salvia miltiorrhiza on blood platelet function and the clinical curative effect on stable angina pectoris. Methods 56 patients with stable angina pectoris were randomly divided into low-dosage depside salt from salvia miltiorrhiza group (group A), high-dosage depside salt from salvia miltiorrhiza group (group B) and Danshen injection control group (group C). Every group was treated for 14 d. The symptom remittence, treadmill test improvement and changes of blood platelet packing fraction and P-selectin in the three groups were observed. Results Blood platelet packing fraction and P-selectin were decreased more in group A and group B than that in group C. Symptoms were alleviated and treadmill test were improved in group A and group B and no significant difference was found compared with group C. Conclusion Dpside salt from salvia miltiorrhiza can obviously inhibit the aggregation and activation of platelet, and can improve symptom of angina pectoris and ST-T changes of ECG.