| 2型糖尿病患者脑海马区氢质子波谱的临床分析 |
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| 引用本文： | 马晓臣,王桂芝,王元春,马方芹,程凯亮.2型糖尿病患者脑海马区氢质子波谱的临床分析[J].现代中西医结合杂志,2010,19(10):1174-1175,1245. |
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| 作者姓名： | 马晓臣 王桂芝 王元春 马方芹 程凯亮 |
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| 作者单位： | 吉林大学中日联谊医院,吉林,长春,130033 |
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| 基金项目： | 吉林市科委计划项目资助课题 |
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| 摘 要： | 目的通过比较2型糖尿病患者与健康对照者海马区磁共振质子波谱(1H-MRS)的差异,探讨2型糖尿病患者脑代谢功能的变化。方法采用1.5T MRI对30例2型糖尿病患者及30例健康人进行1H-MRS检查,检测双侧海马N-乙酰天门冬氨酸复合物(NAA)、胆碱复合物(Cho)与肌酸(Cr)的比值。结果患者组与正常组相比,双侧海马NAA/Cr均降低,而双侧海马Cho/Cr增高。结论2型糖尿病可导致海马区代谢功能紊乱,从而加快脑部功能退化,1H-MRS是检测海马区脑功能变化的有效手段。
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| 关 键 词： | 2型糖尿病 磁共振波谱 海马 |
Clinical analysis of ~1H-MRS in cerebral hippocampus in the patients with non-insulin-dependent diabetes mellitus |
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| Ma Xiaochen,Wang Guizhi,Wang Yuanchun,Ma Fangqin,Cheng Kailiang.Clinical analysis of ~1H-MRS in cerebral hippocampus in the patients with non-insulin-dependent diabetes mellitus[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2010,19(10):1174-1175,1245. |
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| Authors: | Ma Xiaochen Wang Guizhi Wang Yuanchun Ma Fangqin Cheng Kailiang |
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| Institution: | Ma Xiaochen,Wang Guizhi,Wang Yuanchun,Ma Fangqin,Cheng Kailiang(China-Japan Union Hospital,Changchun 130033,Jilin,China) |
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| Abstract: | Objective It is to compare the differences in proton magnetic resonance spectroscopy(1H-MRS) in cerebral hippocampus between patients with non-insulin-dependent diabetes mellitus(NIDDM) and healthy persons to explore the changes of cerebral metabolism in patients with NIDDM.Methods 30 patients with NIDDM and 30 healthy people were detected by 1.5T MRI and 1H-MRSwas applied to determine the metabolic indexes in including NAA/Cr and Cho/Cr in hippocampus in both sides.Results Compared with normal group,NAA/Cr... |
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| Keywords: | non-insulin-dependent diabetes mellitus magnetic resonance ectroscopy Hippocampus |
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