肠胃舒胶囊治疗肿瘤相关腹泻与便秘疗效及调节机制研究

目的 观察肠胃舒胶囊治疗肿瘤相关腹泻与便秘的疗效及调节机制.方法 采用拆随机信封法、多中心竞争入组的临床试验方法,将2018年7月—2019年10月北京中医药大学东直门医院、河南省肿瘤医院、江西省肿瘤医院、广西中医药大学瑞康医院、广西中医药大学第一附属医院、安徽医科大学第一附属医院、中国中医科学院望京医院7家医院诊治的...

Effect and regulation mechanism of Changweishu capsule in the treatment of tumor-related diarrhea and constipation

Objective It is to observe the curative effect and regulation mechanism of Changweishu capsule in the treatment of tumor-related diarrhea and constipation.Methods The patients with tumor chemotherapy-related diarrhea and constipation treated in Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Henan Provincial Cancer Hospital,Jiangxi Provincial Cancer Hospital,The First Affiliated Hospital of Anhui Medical University,Wangjing Hospital of China Academy of Chinese Medical Sciences,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Ruikang Hospital of Guangxi University of Traditional Chinese Medicine from July 2018 to October 2019 were randomly divided into treatment group and control group according to the randomized envelope method and multi-center competitive enrollment in clinical trials.①Tumor chemotherapy-related diarrhea:The treatment group(n=63)was treated with Changweishu capsules(4 capsules/time,3 times a day),the control group(n=30)was treated with Xianglian tablets(5 tablets/time,3 times a day).②Tumor-related constipation:the treatment group(n=33)was treated with Changweishu capsules(4 capsules/time,3 times a day),the control group(n=28)was treated with Ma Ren Run Chang soft capsules(8 capsules/time,twice a day).The duration of treatment was two weeks.All the groups were treated for 2 weeks.The scores of constipation and diarrhea symptoms before and after treatment were recorded in the 2 groups,and the clinical effects of the 2 groups were counted.The levels of serum pepsinogen(PG),vasoactive intestinal peptide(VIP)and cholecystokinin(CCK)were detected before and after treatment in the 2 groups.Results After treatment,the scores of constipation and diarrhea symptoms of the two groups were significantly reduced(both P<0.05),and the scores of diarrhea symptoms of the patients in the treatment group were significantly lower than those of the control group(both P<0.05).The total effective rates of diarrhea and constipation patients in the treatment group were 90.5%(57/63)and 87.9%(29/33),respectively,and the control group were 76.7%(23/30)and 67.8%(19/28),the differences were not statistically significant between the 2 groups(both P>0.05).After treatment,the serum PG level of constipation patients in the two groups showed an increasing trend(P both>0.05),and the serum PG level of diarrhea patients in the control group was increased significantly(P<0.05);after treatment,the serum VIP level of constipation patients in the treatment group had an increasing trend(P>0.05),there was no significant change in diarrhea patients(P>0.05);after treatment,the serum CCK level of constipation patients in the control group was significantly increased(P<0.05).Conclusion Changweishu capsule has two-way regulating effect on tumor chemotherapy-related diarrhea and constipation,it has obvious advantages in reducing diarrhea symptom score.Regulating the levels of PG,VIP and CCK may be one of the potential effect mechanisms of Changweishu capsules in the treatment of constipation and diarrhea.